Infection

Thianthrene (Standard) is the analytical standard of Thianthrene. This product is intended for research and analytical applications. Thianthrene is a potent and orally active inhibitor of Leishmania donovani pteridine reductase 1 (PTR1). Thianthrene is a sulfur-containing tricyclic molecule distributed widely within the macro-structure of hydrocarbon fossil fuels. Thianthrene inhibits the intracellular amastigotes of Leishmania donovani (IC₅₀ = 23 μM). Thianthrene has a moderate anthelmintic activity. Thianthrene appears to inhibit RNA function and subsequent protein production. Thianthrene can stimulate liver regeneration in vivo.

Potassium guaiacolsulfonate (hemihydrate) (Standard) is the analytical standard of Potassium guaiacolsulfonate (hemihydrate). This product is intended for research and analytical applications. Potassium guaiacolsulfonate hemihydrate is an orally active expectorant used for acute respiratory tract infections. Potassium guaiacolsulfonate hemihydrate helps loosen mucus and used for a cough caused by the common cold, infections or allergies in combination with other agents.

Bromuconazole is a triazole fungicide with oral efficacy and blood-brain barrier permeability. Bromuconazole protects crops from various fungal contaminations. Bromuconazole exhibits cytotoxicity against a variety of cancer cells, induces G0/G1 cell cycle arrest and inhibits DNA synthesis in cancer cells, and triggers cytoskeletal structural disorder, genotoxic damage, apoptotic (apoptosis) cell death, and mitochondrial membrane depolarization. Bromuconazole activates caspase-3, induces excessive production of ROS, p53 and Bax, lipid peroxidation, increased activities of SOD and CAT, and downregulates Bcl-2. By upregulating p-ERK1/2 and p-JNK, Bromuconazole disrupts the MAPK signaling pathway, impairs the cellular stress response of human trophoblast cells and endometrial cells, and damages the implantation process. Bromuconazole is applicable to research related to glioma, colon cancer, reproductive injury (implantation dysfunction), and cardiac dysfunction.

Neobulgarone B is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone B can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.

27-Hydroxywithanone is an inhibitor of HIV-1 integrase (HIV-1 integrase). 27-Hydroxywithanone can be used in studies related to HIV-1 infection.

(S)-ZK824859 hydrochloride is a uPA inhibitor and anticoagulant. (S)-ZK824859 hydrochloride can be used for the research of severe acute respiratory syndrome caused by coronavirus and complications thereof .

N-Succinyl-D-alanine, a natural cell wall precursor analogue, is a peptide ligand of antibiotic Ristocetin A.

Dehydrocyclopeptine is an intermediate in the synthesis of benzodiazepine alkaloids in Penicillium.

Shizukanolide F is a dimeric sesquiterpene, which is derivated from Chloranthus japonicus Sieb. Shizukanolide F exhibits potent antifungal activities against various plant pathogenic fungi and anti-metastasis breast cancer.

Cefiderocol (Standard) is the analytical standard of Cefiderocol (HY-17628). This product is intended for research and analytical applications. Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC₅₀s of 2 μg/mL or less.

Juglomycin B has a broad spectrum of antibacterial and mycobacterial effects, and has the effect of inhibiting ehrlician ascites cancer in mice and prolongating life with 1 mg/kg.

Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

Neomycin C is an impurity of Neomycin (HY-150520) and a stereoisomer of Neomycin B (HY-17624). Neomycin C exerts in vitro antimicrobial activity against Staphylococcus epidermidis and Staphylococcus aureus. Neomycin C can be used for the research of bacterial infection.

Rufigallol is one of the earliest systems reported to form columnar mesophases. Rufigallol is also an oxidant agent. Rufigallol acts in a pro-oxidant fashion to produce oxygen radicals inside parasitized erythrocytes. Rufigallol has vitamin K activity and antimalarial activity.

Antifungal agent 151 is a Prp8 intein inhibitor that inhibits the self-splicing process of the Prp8 intein, preventing maturation of the Prp8 protein. Antifungal agent 151 exerts in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 can be used for the research of cryptococcus pneumonia.

Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC₅₀ of 83 nM against *Plasmodium falciparum* and an IC₅₀ of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research.

(Rac)-Moxifloxacin-d₄ ((Rac)-BAY 12-8039-d₄ (free base)) is deuterium labeled (Rac)-Moxifloxacin. (Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is the isoform of Moxifloxacin Hydrochloride (HY-66011), which is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.

Gangamicin (Compound 3) is an Antibacterial agent. Gangamicin potently inhibits the growth of Mycobacterium tuberculosis with a MIC of 3.5 μM. Gangamicin can be used in the research of tuberculosis.

L-731128 is a novel alkyl citrate. L-731128 can be isolated as a minor component of Sporormiella intermedia (MF 5447, ATCC 20985) fermentations. L-731128 is a potent squalene synthase inhibitor, with an IC₅₀ value of 767 nM.

gp120-IN-3 (Compound 11) is a HIV-1 gp120 inhibitor with an IC₅₀ value of 1.64 nM, which can be utilized in HIV research.