Neurological Disease

SLL-022CCP is a KOR-selective, high affinity and extremely potent agonist with an EC₅₀ of 9.1 nM and a K_i of 2.0 nM. SLL-022CCP inhibits cAMP production with an EC₅₀ of 0.002 nM, and exhibits high receptor subtype selectivity over the μ-opioid receptor (MOR, EC₅₀ = 1.6 nM) and δ-opioid receptor (DOR, EC₅₀ = 30.0 nM). SLL-022CCP exhibits robust antinociceptive and antipruritic effects with low central side effects.

Selaginella extract (Selaginella tamariscina extract) is an extract of Selaginella that can be used in pain research.

Obtusinaphthalenside B is a novel naphthyl glycoside compound that can be isolated from Cassia obtusifolia seeds. Cassia obtusifolia has physiological functions related to neuroprotection, anti-inflammation, and hepatoprotection.

6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis.

SR 57227A Free base is a highly selective compound for both peripheral and central 5-HT3 receptors and acts as an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells, demonstrating antidepressant-like effects in rats while reducing isolation-induced aggressive behavior.

SBN-284 (compound 3x) is a dual inhibitor of blood-brain permeable Cholinesterases and the NLRP3 inflammasome and is effective against EeAChE, hAChE and eqBChE, the IC₅₀ values of are 0.37, 0.31, 0.29 μM respectively, and the EC₅₀ of NLRP3 inflamm is 1 μM. SBN-284 can be used in Alzheimer's disease research.

Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, and galanin itself.

mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages.

3-Ethyl-3-methylthiolan-2-one is an antiepileptic agent that inhibits GABA_A receptors.

5-HT6R antagonist 5 (compound 1.2.12(4)) is a potent competitive 5-HT6R antagonist with an IC₅₀ of 4.19 nM. 5-HT6R antagonist 5 can be used for research in various central nervous system (CNS) diseases, cognitive and neurodegenerative diseases.

TRR469 is a positive allosteric modulator of the A₁ adenosine receptor (A₁AR). TRR469 significantly increases the affinity of 2-chloro N(6)-cyclopentyladenosine (CCPA) for A₁AR, increasing the number of receptors recognized by the agonist radioligand [³H]-CCPA. TRR469 shows significant effects in both anxiety and pain models. TRR469 can be used to study anxiety disorders and pain management.

p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators.

NMDAR modulator 3 is a subunit-selective NMDA receptor potentiator targeting NMDAR receptors containing NR2C/NR2D subunits. NMDAR modulator 3 can be used for the research of schizophrenia, parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, neurodegeneration.

Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS).

Gamma-glutamyl-beta-cyanoalanine (γ-Glutamyl-β-cyanoalanine), a dipeptide, is a neurotoxin found in Seeds of common vetch.

7-Methoxy-4H-chromen-4-one-o-carborane is an ER agonist and COX inhibitor with a COX-1 IC₅₀ of 3.0 μM, COX-2 IC₅₀ of 1.0 μM. 7-Methoxy-4H-chromen-4-one-o-carborane can be used for research on antimicrobial, anti-inflammatory, antitumor, neuroprotective, and estrogenic effects.

N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist.

D-Galactose-¹³C-4 is the ¹³C labeled D-Galactose. D-Galactose is a natural aldohexose and C-4 epimer of glucose.

PD-161182 is a non-peptide NK-3 antagonist. PD-161182 can be studied in NK-3-related central nervous system disturbances, pain, inflammation, pulmonary and skin diseases.

para-Methylaminorex is structurally similar to known stimulants.