1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. SQ-31765

SQ-31765 (Synonyms: SQ31765; SQ 31765)

Cat. No.: HY-101740
Handling Instructions

SQ-31765 is a benzazepine calcium channel blocker.

For research use only. We do not sell to patients.

SQ-31765 Chemical Structure

SQ-31765 Chemical Structure

CAS No. : 138383-07-0

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SQ-31765 is a benzazepine calcium channel blocker.

IC50 & Target

Calcium channel[1]

In Vivo

SQ-31765 (SQ 31,765) can reduce the severity of ischemia in a manner which is independent of changes in myocardial blood flow or hemodynamic alterations. Anesthetized dogs are given saline (n=6), SQ-31765 (n=6; 0.2 mg/kg) or SQ 32,189 (n=6; 0.2 mg/kg) i.v. 10 min before ischemia. The effect on pacing-induced ST-segment elevation (pacing+left anterior descending coronary artery stenosis) and myocardial blood flow are determined. SQ-31765 reduces ST-elevation (P<0.05) compared to saline at 10, 40 and 70 min after infusion (5.9±1.4 and 12.0±1.4 mV, respectively, at 70 min). Left anterior descending coronary artery stenosis during atrial pacing resulted in a significant reduction in subendocardial flow in all groups before drug infusion (41±7, 44±7 and 35±9 mL/min/100 g for saline, SQ-31765 and SQ 32,189, respectively)[1].

Molecular Weight







O=C1N(CCN(C)C)C2=CC=CC(C(F)(F)F)=C2C[[email protected]@H](C3=CC=C(OC)C=C3)[[email protected]]1OC(C)=O


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