AChE Inhibitor

BW284C51 is a highly selective Acetylcholinesterase inhibitor. BW284C51 exerts non-competitive, voltage-dependent blocking effects on the Torpedo nicotinic acetylcholine receptor channel. BW284C51 impairs acetylcholine clearance to increase acetylcholine exposure, and enhances the acetylcholine-mediated expression response of melanogenesis-related genes. BW284C51 can be used in research related to Alzheimer's disease, Parkinson's disease, congenital myasthenia, schizophrenia and familial epilepsy.

Insecticidal agent 38 is a AChE inhibitor and Insecticide, with an IC₅₀ of 49.08 μg/mL against AChE. Insecticidal agent 38 inhibits the activities of SOD, Catalase and Glutathione-S-transferase. Insecticidal agent 38 induces intracellular ROS, lipofuscin and lipid accumulation, increases malondialdehyde levels, disrupts redox homeostasis and triggers oxidative damage. Insecticidal agent 38 inhibits the feeding and reproductive capabilities of the pine wood nematode (Bursaphelenchus xylophilus). Insecticidal agent 38 exhibits insecticidal activity against nematodes. Insecticidal agent 38 can be used in studies of plant-parasitic nematode infections.

Phorate sulfone, Phorate metabolite, is an insecticide. Phorate sulfone shows inhibitory activity aainst acetylcholinesterase with an IC₅₀ of 40 μM, leading to acetylcholine accumulation at cellular and subcellular levels. Phorate sulfone can be used for the research of severe phorate poisoning.

AChE/nAChR-IN-1 (Compound 1a) is dual-functional inhibitor of AChE and nAChR. AChE/nAChR-IN-1 has potent toxicity and larvicidal effectiveness against Culex pipiens larvae with a LC₅₀ of 4 ng/mL. AChE/nAChR-IN-1 can be used as larvicides for mosquito-borne diseases research.

Isodimethoate is a thermal decomposition product of Dimethoate (HY-B1946). Isodimethoate is a direct anticholinesterase agent and shows an inhibition to human red blood cell acetylcholinesterase (AChE).

Dihydrokaempferol-3-O-β-D-glucoside (Compound 3) is a compound that can be isolated from the bark of Cudrania tricuspidata (Carr.) Bur. . Dihydrokaempferol-3-O-β-D-glucoside is an inhibitor of acetylcholinesterase (AChE).

Anabasamine is an alkaloid. Anabasamine can be isolated from the aerial parts of Anabasis aphylla L. As an inhibitor of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE), Anabasamine has a pK_i value of 3.49 against AChE and 2.08 against BuChE.

Galactamine is an AChE inhibitor. Galactamine can be used in the research of Alzheimer's disease.

Ganstigmine (CHF 2819 free base) is a potent, orally active, blood-brain barrier-permeable acetylcholinesterase (AChE) inhibitor, with an IC₅₀ value of 65 nM against human AChE, 310 nM against human butyrylcholinesterase (BChE), and 5.12 μM against Torpedo californica AChE. Ganstigmine increases extracellular acetylcholine levels in the brain of rodents without altering the concentrations of other neurotransmitters, stimulates cholinergic transmission, and induces the release of soluble non-amyloidogenic amyloid precursor protein. Ganstigmine exhibits neuroprotective activity independent of cholinesterase inhibition, prevents neuronal death, alleviates β-amyloid-induced neurodegeneration, rescues cholinergic neuron loss, and reverses Scopolamine (HY-N0296)-induced amnesia and memory deficits. Ganstigmine shows cholinesterase inhibition-independent neuroprotective effects against growth factor deprivation and Aβ_25-35 toxicity. Ganstigmine can be used in research on Alzheimer's disease, cholinergic dysfunction, and neuroprotection.

AD-35 free base is an orally active, blood-brain barrier-permeable acetylcholinesterase inhibitor with an IC₅₀ of 793 nM. AD-35 free base inhibits metal-induced amyloid-β aggregation and disassembles preformed amyloid-β aggregates. In rat models of cognitive impairment, AD-35 free base attenuates Aβ_25-35-induced astrocyte activation, TNF-α and IL-1β release, inhibits ERK phosphorylation, and alleviates learning and memory deficits. AD-35 free base can be used for research on Alzheimer's disease.

Methyl ganoderate A acetonide, a lanostane triterpene, is a natural product that could be isolated from the fruiting bodies of Ganoderma lucidum. Methyl ganoderate A acetonide is a potent AChE inhibitor with an IC₅₀ value of 18.35 μM. Methyl ganoderate A acetonide can be used in research of Alzheimer’s disease (AD).

AChE-IN-115 is an acetylcholinesterase (AChE) inhibitor. AChE-IN-115 forms stable complexes with AChE from Spodoptera litura (tobacco cutworm) and Tribolium castaneum (red flour beetle). AChE-IN-115 exhibits insecticidal activity.

TAE-1 is a potent inhibitor of AChE and BuChE. TAE-1 also inhibits Aβ fibril formation and aggregation. TAE-1 can be used for the researches of Alzheimer's disease.