402-40-4
Chemical Structure
BW284C51
- CAS. Nr.: 402-40-4
- Formula:C27H38Br2N2O
- Molecular Weight:566.41
IUPAC Name: 4,4'-(3-oxopentane-1,5-diyl)bis(N-allyl-N,N-dimethylbenzenaminium) bromide
InChIKey: WKDURMTZOWGWTD-UHFFFAOYSA-L
SMILES: O=C(CCC1=CC=C([N+](C)(C)CC=C)C=C1)CCC2=CC=C([N+](C)(C)CC=C)C=C2.[Br-].[Br-]
Biological Activity: BW284C51 is a highly selective Acetylcholinesterase inhibitor. BW284C51 exerts non-competitive, voltage-dependent blocking effects on the Torpedo nicotinic acetylcholine receptor channel. BW284C51 impairs acetylcholine clearance to increase acetylcholine exposure, and enhances the acetylcholine-mediated expression response of melanogenesis-related genes. BW284C51 can be used in research related to Alzheimer's disease, Parkinson's disease, congenital myasthenia, schizophrenia and familial epilepsy[1][2][3].
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BW284C51 | BW284C51 is a highly selective Acetylcholinesterase inhibitor. BW284C51 exerts non-competitive, voltage-dependent blocking effects on the Torpedo nicotinic acetylcholine receptor channel. BW284C51 impairs acetylcholine clearance to increase acetylcholine exposure, and enhances the acetylcholine-mediated expression response of melanogenesis-related genes. BW284C51 can be used in research related to Alzheimer's disease, Parkinson's disease, congenital myasthenia, schizophrenia and familial epilepsy. | |||||||||||||||||||||
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References
- [1]. Jacobson S, et al. Acetylcholine Affects the Endothelial Marrow Niche: Implications for Engraftment[J]. Transplantation and Cellular Therapy, Official Publication of the American Society for Transplantation and Cellular Therapy, 2026, 32(2): S328.
- [2]. Olivera-Bravo S, et al. The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. British journal of pharmacology. 2005 Jan;144(1):88-97.
- [3]. Wu Q, et al. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. The Journal of biological chemistry. 2018 Sep 14;293(37):14417-14428.
