Insecticidal agent 38

Insecticidal agent 38 (Compound B10) at concentrations of 50-200 μg/mL efficiently induces 100% mortality in Bursaphelenchus xylophilus (pine wood nematode), Aphelenchoides besseyi (rice white-tip nematode) and Ditylenchus destructor (potato rot nematode), with LC₅₀ values of 5.85 μg/mL, 12.23 μg/mL and 17.33 μg/mL, respectively^[1].
Insecticidal agent 38 (12.5-200 μg/mL; 3-48 h) exhibits time- and concentration-dependent nematicidal activity against the pine wood nematode (Bursaphelenchus xylophilus). After 48 h of treatment, the nematode mortality reaches 100% at concentrations of 200 μg mL^-1 and 100 μg mL^-1[1].
Insecticidal agent 38 (200 μg/mL; 3-48 h) impairs the locomotor behavior of the pine wood nematode (Bursaphelenchus xylophilus), reducing the frequencies of head swinging and body bending to 0 at 48 h post-treatment^[1].
Insecticidal agent 38 (10-20 μg/mL; 48 h) inhibits the reproductive capacity of Bursaphelenchus xylophilus in a concentration-dependent manner, and its reproduction rate decreases to 7.83% after treatment with 20 μg mL^-1 for 48 h^[1].
Insecticidal agent 38 (10 μg/mL; 48 h) alters the transcriptome of Bursaphelenchus xylophilus, with significantly enriched down-regulated genes in the neuroactive ligand-receptor interaction pathway, which is verified by qRT-PCR after 48 h of treatment^[1].
Insecticidal agent 38 (48 h) inhibits acetylcholinesterase activity of the pine wood nematode (Bursaphelenchus xylophilus), with an IC₅₀ value of 49.08 μg mL⁻¹ after 48 h of treatment^[1].
Insecticidal agent 38 forms a variety of stable interactions with amino acid residues in the active site of acetylcholinesterase (PDB ID: 6H14), indicating that it is a potential AChE inhibitor^[1].
Insecticidal agent 38 (10-20 μg/mL; 48 h) induces concentration-dependent accumulation of ROS, lipofuscin and lipids in Bursaphelenchus xylophilus. After treatment with 20 μg mL^-1 for 48 h, the contents of the three substances increase by 2.35-fold, 3.13-fold and 3.11-fold, respectively^[1].

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