2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aminopeptidase

Aminopeptidase

Aminopeptidase

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Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates. Regarding catalytic mechanism, most of the aminopeptidases are metallo-enzymes but cysteine and serine peptidases are also included in this group. Aminopeptidases are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Several aminopeptidases perform essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes and are inhibited by the transition-state analog bestatin. Some are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits.

Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or inactive angiotensin peptides that alter the ratios between their bioactive forms, regulating several important processes such as the regulation of cardiovascular functions, body water regulation, normal memory consolidation and retrieval, but also cell growth, differentiation and apoptosis or the inflammatory response.

Aminopeptidase Isoform Specific Products:

Aminopeptidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W015876
    L-Leucinol
    		Inhibitor 99.53%
    L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with a Ki value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex.
    L-Leucinol
  • HY-139907B
    DG013A formate
    		Inhibitor 99.57%
    DG013A (formate) is a phosphinic acid tripeptide mimetic inhibitor. DG013A (formate) displays significantly weak affinity for both ERAP1 (IC50=33 nM) and ERAP2 (IC50=11 nM). DG013A (formate) can be used for the research of autoimmune disease and cancer.
    DG013A formate
  • HY-151518
    Aminopeptidase-IN-1
    		Inhibitor 98.25%
    Aminopeptidase-IN-1 (compound 16o) is an insulin-regulated aminopeptidase (IRAP) inhibitor with an Ki value of 7.7 μM. Aminopeptidase-IN-1 inhibits catalytic activity of IRAP.Aminopeptidase-IN-1 can be used for the research of memory impairments.
    Aminopeptidase-IN-1
  • HY-128090A
    Apstatin TFA
    		Inhibitor 99.57%
    Apstatin TFA is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin TFA shows cardioprotection.
    Apstatin TFA
  • HY-110259
    HFI-142
    		Inhibitor 99.55%
    HFI-142 is an insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 2.01 μM.
    HFI-142
  • HY-169915
    ERAP1 modulator-2
    		Inhibitor 98.93%
    ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of <100 nM.
    ERAP1 modulator-2
  • HY-160239
    HFI-437
    		Inhibitor 99.64%
    HFI-437 is a potent non-peptidic insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 20 nM. HFI-437 is a cognitive enhancer.
    HFI-437
  • HY-W040088
    L-Alanyl-L-leucine
    		Inhibitor 98.15%
    L-Alanyl-L-leucine is a competitive inhibitor of small intestinal glycyl-L-leucine hydrolase with Ki values of 0.53 mM (phosphate buffer) or 0.22 mM (Tris buffer). L-Alanyl-L-leucine can be used for research on Hartnup disease and cystinuria.
    L-Alanyl-L-leucine
  • HY-W027340
    ARM1
    		Inhibitor 99.60%
    ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC50 7.61 µM and epoxide hydrolase inhibitory activity with an IC50 12.4 µM.
    ARM1
  • HY-150504
    ERAP2-IN-1
    		Inhibitor 98.86%
    ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM.
    ERAP2-IN-1
  • HY-W012888
    D-Leucinol
    		Control 99.71%
    D-Leucinol is the isomer of L-Leucinol (HY-W015876), and can be used as an experimental control. L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with Ki value of 17 μM.
    D-Leucinol
  • HY-B0134AS
    Bestatin-d7 hydrochloride
    		Inhibitor
    Bestatin-d7 (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.
    Bestatin-d<sub>7</sub> hydrochloride
  • HY-W004291
    Methyl arachidate
    		Inhibitor 98.0%
    Methyl arachidate (Methyl icosanoate) is a component of lipid mixtures. Methyl arachidate can be isolated from flowering plants. Methyl arachidate inhibits LTA4H. Methyl arachidate shows no antifeedant activity against Leptinotarsa decemlineata.
    Methyl arachidate
  • HY-W097753
    4-MDM
    		99.64%
    4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases.
    4-MDM
  • HY-W009906
    2-(2′-Pyridyl)benzimidazole
    		Inhibitor 99.88%
    2-(2’-Pyridyl)benzimidazole is a potentially tridentate ligand that can form stable complexes with various transition metal ions. 2-(2’-Pyridyl)benzimidazole can be used as an anti-inflammatory agent and an inhibitor of Escherichia coli methionine aminopeptidase.
    2-(2′-Pyridyl)benzimidazole
  • HY-137159
    Bestatin methyl ester
    		Inhibitor
    Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation.
    Bestatin methyl ester
  • HY-121123
    Adamantanine
    		Inhibitor
    Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5.
    Adamantanine
  • HY-137528
    H-Glu(4MβNA)-OH
    		Substrate 99.0%
    H-Glu(4MβNA)-OH is a substrate of aminopeptidases (APs).
    H-Glu(4MβNA)-OH
  • HY-N8760
    Batatasin IV
    		Inhibitor 98.33%
    Batatasin IV is an LTA4H inhibitor with anti-inflammatory activity. Batatasin IV is also a natural product that can be obtained from Dioscorea batatus. Batatasin IV can be used in research in the area of inflammation.
    Batatasin IV
  • HY-117702
    RB 101
    		Inhibitor
    RB 101 is an active mixed inhibitor against two enzymes which metabolize the enkephalins neutral endopeptidase and aminopeptidase N. RB 101 has rather long-lasting antinociceptive effects. RB 101 inhibits the in vivo [3H]DPN binding both under basal conditions and after swim stress in mice. RB 101 can be used to determine the precise in vivo localization of enkephalinergic pathways recruited by various stimuli.
    RB 101
Cat. No. Product Name / Synonyms Application Reactivity
Aminopeptidase Isoform Comparison

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