Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (300)
Related Products (300)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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Azilsartan mopivabil
0 ImagesAzilsartan mopivabil is the potent antagonist of angiotensin II receptor.
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Olodanrigan sodium
0 ImagesCat. No.: HY-13106ACAS No.: 1316755-17-5Synonyms: EMA401 sodium; PD-126055 sodiumOlodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
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Irbesartan hydrochloride
0 ImagesCat. No.: HY-B0202ACAS No.: 329055-23-4Synonyms: SR-47436 hydrochloride; BMS-186295 hydrochlorideIrbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
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Eprosartan-d3
0 ImagesCat. No.: HY-117743SCAS No.: 1185243-70-2Eprosartan-d3 is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
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Losartan-d3 Carboxylic Acid
0 ImagesCat. No.: HY-17512S1CAS No.: 1189729-40-5Losartan-d3 Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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Ripisartan
0 ImagesCat. No.: HY-119544CAS No.: 148504-51-2Synonyms: UP-2696Ripisartan (UP-2696) is an angiotensin II receptor antagonist. Ripisartan is orally available. Ripisartan binds to angiotensin II receptors, dilates blood vessels, and lowers blood pressure.
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AT2R antagonist 1
0 ImagesCat. No.: HY-146410CAS No.: 2709031-17-2AT2R antagonist 1 (compound 21) is a potent and high selective AT2R (angiotensin II AT2 receptor) ligand. AT2R antagonist 1 exhibits a fair AT2R affinity, with a Ki of 29 nM. AT2R antagonist 1 also inhibits common agent-metabolizing CYP enzymes. AT2R antagonist 1 shows high stability in human, rat and mouse liver microsomes.
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(Sar1,Gly8)-Angiotensin II
0 ImagesCat. No.: HY-P11389CAS No.: 51887-62-8(Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (Ki: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II.
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CR 3834
0 ImagesCat. No.: HY-105298CAS No.: 868741-81-5CR 3834 is a angiotensin-AT1 antagonist. CR 3834 can be used for the research of cardiovascular disease.
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CI-996
0 ImagesCat. No.: HY-19165CAS No.: 150438-02-1CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [125I]Ang II with an IC50 of 0.8 nM. CI-996 has blood pressure-lowering activity.
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BMS-248360
0 ImagesCat. No.: HY-114953CAS No.: 254737-87-6BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects.
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Eprosartan mesylate (Standard)
0 ImagesCat. No.: HY-15834ARCAS No.: 144143-96-4Synonyms: SKF-108566J (Standard)Eprosartan (mesylate) (Standard) is the analytical standard of Eprosartan (mesylate). This product is intended for research and analytical applications. Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively.
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Pomisartan
0 ImagesCat. No.: HY-106123CAS No.: 144702-17-0Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC50=0.26 μM). Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect.
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DMP 811
0 ImagesCat. No.: HY-180401CAS No.: 139964-19-5DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension.
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KRH-594
0 ImagesCat. No.: HY-19253ACAS No.: 167006-13-5KRH-594 is an orally active angiotensin AT1 receptor antagonist. KRH-594 ameliorates the progression of diabetic nephropathy and hyperlipidaemia. KRH-594 inhibits cardiac hypertrophy.
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Telmisartan-d4
0 ImagesCat. No.: HY-13955S1Synonyms: BIBR 277-d4Telmisartan-d4 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
