Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (302)
Related Products (302)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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SC-51316
0 ImagesCat. No.: HY-120776CAS No.: 133690-62-7SC-51316 is an oral active angiotensin II receptor antagonist with the IC50 values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro.
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(Rac)-Valsartan-d9
0 ImagesCat. No.: HY-18204S3Synonyms: (Rac)-CGP 48933-d9(Rac)-Valsartan-d9 is deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
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EMD-66684 potassium salt
0 ImagesCat. No.: HY-103247BCAS No.: 187683-79-0EMD-66684 potassium salt is a non-peptide angiotensin II receptor antagonist that demonstrates significant antihypertensive effects in spontaneously hypertensive rats. EMD-66684 potassium salt exhibits nanomolar affinity for angiotensin II receptors, comparable to losartan in potency. EMD-66684 potassium salt shows increased activity when modified with acetamides, leading to superior blood pressure reduction.
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Telmisartan (Standard)
0 ImagesSynonyms: BIBR 277 (Standard)Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
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Cytosporin A
0 ImagesCat. No.: HY-N14205CAS No.: 175521-93-4Cytosporin A is a hexahydrobenzopyran derivative and an angiotensin II receptor antagonist. Cytosporin A has IC50 values of 25-30 μM and 1.5-3 μM for AT1 and AT2, respectively.
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AT1R antagonist 1
0 ImagesCat. No.: HY-146431CAS No.: 2848719-80-0AT1R antagonist 1 (compound 10) is a potent AT1R selective ligand. AT1R antagonist 1 exhibits a fair AT1R affinity, with a Ki of 8.5 nM.
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Milfasartan
0 ImagesCat. No.: HY-101542CAS No.: 148564-47-0Synonyms: LR-B/081Milfasartan (LR-B/081) is a selective angiotensin receptor AT1 antagonist with antihypertensive activity.
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Norleual
0 ImagesCat. No.: HY-P1415CAS No.: 334994-34-2Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
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Saralasin acetate hydrate
0 ImagesCat. No.: HY-P0205ACAS No.: 39698-78-7Synonyms: [Sar1,Ala8] Angiotensin II acetate hydrateSaralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
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Fonsartan free acid
0 ImagesCat. No.: HY-119379CAS No.: 144628-52-4Synonyms: HOE-720 free acidFonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases.
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Saprisartan potassium
0 ImagesCat. No.: HY-A0229ACAS No.: 146613-90-3Synonyms: GR 138950 potassiumSaprisartan (GR 138950) potassium is a selective, long-acting AT1 receptor antagonist.
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A-779 TFA
0 ImagesCat. No.: HY-P0216AA-779 TFA is a selective angiotensin-(1-7) (Ang-(1-7)) antagonist. A-779 TFA blocks Arachidonic acid release, bradykinin potentiation effects and hypotensive action. A-779 TFA exerts diuretic effects in non-pregnant rats, antidiuretic effects in late-pregnant rats, and also inhibits feed intake and water consumption in late-pregnant rats. A-779 TFA attenuates the regulatory effects of prostacyclin, nitric oxide and thromboxane A2 associated with angiotensin-(1-7). A-779 TFA can be used in studies related to hypertension.
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Antihypertensive agent 2
0 ImagesCat. No.: HY-155041CAS No.: 3049677-56-4
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AT1R antagonist 2
0 ImagesCat. No.: HY-146436CAS No.: 2848719-76-4AT1R antagonist 2 (compound 6) is a potent AT1R selective ligand. AT1R antagonist 2 exhibits a fair AT1R affinity, with a Ki of 26 nM.
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LY303336
0 ImagesCat. No.: HY-117447CAS No.: 157187-00-3LY303336 is an antagonist of polysubstituted 4-aminoimidazole AT1 receptor with an IC50 value of 5.2 nM.
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Irbesartan (Standard)
0 ImagesSynonyms: SR-47436 (Standard); BMS-186295 (Standard)Irbesartan (Standard) is the analytical standard of Irbesartan. This product is intended for research and analytical applications. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
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Forasartan
0 ImagesCat. No.: HY-A0224CAS No.: 145216-43-9Synonyms: SC-52458Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II.
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Losartan carboxylic acid-d4 hydrochloride
0 ImagesCat. No.: HY-12765S1Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
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ICI-D 8731
0 ImagesCat. No.: HY-19155ACAS No.: 135015-84-8Synonyms: ZD-8731ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC50 of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model.
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YM-358 hydrate potassium
0 ImagesCat. No.: HY-105011ACAS No.: 161800-08-4YM-358 hydrate potassium is an orally active angiotensin II type 1 (AT1)-receptor antagonist. YM-358 hydrate potassium can decrease cardiac volume overload. YM-358 hydrate potassium can be used for the research of cardiovascular disease, such as hypertension.
