Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (300)
Related Products (300)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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Azilsartan mepixetil potassium
0 ImagesCat. No.: HY-145552ACAS No.: 2153458-32-1Synonyms: QR-01019KAzilsartan mepixetil potassium (QR-01019K) is the antagonist of angiotensin II receptor. Azilsartan mepixetil potassium has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil potassium has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).
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LY 301875
0 ImagesCat. No.: HY-105440CAS No.: 154668-27-6LY 301875 is a potent and orally active angiotensin II receptor type 1 (AT1) antagonist with a pKB value of 9.6.
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L-158809
0 ImagesCat. No.: HY-114586CAS No.: 133240-46-7L-158809 is an angiotensin type 1 (AT1) receptor antagonist that prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. L-158809 is promising for research of brain tumor.
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Tolmesoxide
0 ImagesCat. No.: HY-107037CAS No.: 38452-29-8Synonyms: RX71107Tolmesoxide (RX71107) is a peripheral vascular dilator with blood pressure lowering activity. Tolmesoxide has shown direct vasodilation in the human forearm arterial bed and dorsal hand vein. Tolmesoxide can dose-dependently increase blood flow in the forearm and produce dilation during contraction of the dorsal hand veins. Tolmesoxide can be used to study high blood pressure and angina.
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Embusartan
0 ImagesCat. No.: HY-121313CAS No.: 156001-18-2Synonyms: BAY 10-6734Embusartan (BAY 10-6734) is a brain-penetrant and effective AT1 receptor blocker. Embusartan inhibits Ang II binding to brain AT1 receptors in the nuclei of central nervous system (CNS) inside due to high lipophilic character. Embusartan is promising for research of sympathetic hyperactivity and hypertension.
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BMS 183920
0 ImagesCat. No.: HY-120134CAS No.: 153072-33-4BMS 183920 is a diacidic and potent angiotensin II receptor antagonist, with a Ki value of 2.9 nM in the rat adrenal cortex binding assay and a KB value of 0.061 nM in the rabbit aorta functional assay. BMS 183920 can be used for research of antihypertensive.
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EXP-6803
0 ImagesCat. No.: HY-10382CAS No.: 114773-44-3EXP-6803 is a specific nonpeptide angiotensin II receptor antagonist with antihypertensive activity. EXP-6803 inhibits the contractile response to angiotensin II with a pA2 value of 7.20. EXP-6803 effectively blocks responses to angiotensin I and II while not affecting responses to bradykinin or acetylcholine in guinea pig ileum. EXP-6803 can be used for hypertension research.
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Sparsentan-d5
0 ImagesCat. No.: HY-17621SCAS No.: 1801597-09-0Synonyms: RE-021-d5; DARA-a-d5Sparsentan-d5 is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.
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Eprosartan-d6
0 ImagesCat. No.: HY-117743S1Synonyms: SKF-108566J free base-d6Eprosartan-d6 is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .
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L-163958
0 ImagesCat. No.: HY-114284CAS No.: 168473-51-6L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases.
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[Sar1,Thr8]-Angiotensin II
![[Sar1,Thr8]-Angiotensin II](https://file.medchemexpress.com/product_pic/hy-p10640.gif "Click to View [Sar1,Thr8]-Angiotensin II Product Detail")
0 ImagesCat. No.: HY-P10640CAS No.: 53632-49-8[Sar1,Thr8]-Angiotensin II is a potent angiotensin II antagonist. [Sar1,Thr8]-Angiotensin II does not alter cardiac performance. [Sar1,Thr8]-Angiotensin II might be safe for patients with cardiac disease.
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Fonsartan
0 ImagesCat. No.: HY-19224CAS No.: 153235-15-5Synonyms: HR 720Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI).
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Saprisartan
0 ImagesCat. No.: HY-A0229CAS No.: 146623-69-0Synonyms: GR 138950Saprisartan (GR 138950) is a selective, long-acting AT1 receptor antagonist with low receptor dissociation kinetics.
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PD 121981
0 ImagesCat. No.: HY-105453CAS No.: 114785-18-1Synonyms: WL 19PD 121981 is a angiotensin II receptor antagonist. PD 121981 can be used for the research of cardiovascular disease.
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Telmisartan-13C,d3
0 ImagesCat. No.: HY-13955S2CAS No.: 1261396-33-1Synonyms: BIBR 277-13C,d3Telmisartan-13C,d3 is the 13C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
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KR31173
0 ImagesCat. No.: HY-165425CAS No.: 260554-07-2KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice.
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L-163017
0 ImagesCat. No.: HY-114283CAS No.: 169281-98-5L-163017 is a potent, orally active and nonpeptide angiotensin II receptor (AT) antagonist. L-163017 can inhibit prevent the pressor response to angiotensin II and reduce blood pressure. L-163017 can be used for the research of cardiovascular disease, such as hypertension.
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EXP-7711
0 ImagesEXP-7711 is a non peptide angiotensin II (Ang II) AT1 receptor antagonist. EXP-7711’s affinity for wild-type AT1 receptor (Ki =180 nM) is lower than peptide antagonists, but higher than losartan (Ki = 12 nM). EXP-7711 can be used for research on cardiovascular conditions.
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L-163007
0 ImagesCat. No.: HY-114282CAS No.: 1026784-27-9L-163007 is an orally active AT1/2 receptor antagonist. L-163007 can be used for the research of cardiovascular disease, such as hypertension.
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AT1R antagonist 3
0 ImagesCat. No.: HY-159090CAS No.: 3053482-15-5AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV1.2 (IC50=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models.
