Bradykinin Receptor
Bradykinin receptors are cell surface, G protein-coupled receptor (GPCR) family members. There are two subtypes of bradykinin receptors, B1 and B2. Bradykinin receptor-mediated signal transductions play a significant role in maintaining cardiovascular homeostasis, regulating pain and inflammation. Both receptors transduce extracellular signals through the activation of G-proteins.
Bradykinin B1 receptor is expressed at a very low level in healthy tissues, but is induced under stressful conditions such as shock or inflammation, whereas the bradykinin B2 receptor is ubiquitous and is constitutively expressed. Bradykinin B2 receptor is involved in vasodilation, osmoregulation, smooth muscle contraction, and nociceptor activation. Bradykinin B1 receptor and Bradykinin B2 receptor have emerged as therapeutic targets as they are implicated in inflammatory disease, vasculopathy, neuropathy, obesity, diabetes, and cancer. B1R and B2R can hold dichotomous roles in diseases. Agonists and antagonists have been evaluated as therapeutics.
Bradykinin Receptor Isoform Specific Products
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Bradykinin Receptor Related Products (70)
Related Products (70)
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Antibodies (1)
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Bradykinin Receptor Isoform Comparison
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[Phe8Ψ(CH-NH)Arg9]-Bradykinin
![[Phe8Ψ(CH-NH)Arg9]-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103292.gif "Click to View [Phe8Ψ(CH-NH)Arg9]-Bradykinin Product Detail")
0 ImagesCat. No.: HY-103292CAS No.: 118122-39-7[Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective Bradykinin receptor B2 agonist (not cleaved by protein kinase I/II). [Phe8Ψ(CH-NH)Arg9]-Bradykinin has potential for the research of hypertension.
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NPC-567
0 ImagesCat. No.: HY-P2118CAS No.: 109333-26-8NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways.
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Thrombostatin cont-1
0 ImagesCat. No.: HY-P3973CAS No.: 929555-19-1Thrombostatin cont-1 is an analogue of thrombostatin, which is a a bradykinin metabolite. Thrombostatin could decrease platelet activation in the canine carotid artery model of balloon angioplasty (BA) injury.
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Emorfazone
0 ImagesCat. No.: HY-126609CAS No.: 38957-41-4Synonyms: Pentoil; NandronEmorfazone (Pentoil) is a non-steroidal anti-inflammatory drug with oral activity. Emorfazone can significantly inhibit the release of bradykinin-like substances and kininogen. Emorfazone has anti-inflammatory and analgesic activity.
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Icatibant (Standard)
0 ImagesSynonyms: HOE 140 (Standard)Icatibant (Standard) is the analytical standard of Icatibant. This product is intended for research and analytical applications. Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
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B 4310
0 ImagesCat. No.: HY-P2027CAS No.: 103412-40-4B 4310 is a non-organ-selective Bradykinin antagonist. B 4310 induces uterine contraction in rats. B 4310 blocks bradykinin-mediated responses, including substance P release, plasma extravasation, venous contraction, prostaglandin E2 release and trigeminal nerve stimulation, but exerts no effect on angiotensin II, acetylcholine or capsaicin pathways. B 4310 exerts a reversible antagonistic effect on bradykinin-induced nociceptors. B 4310 serves as a tool for investigating the biological effects of bradykinin.
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Lys-Bradykinin tetraacetate
0 ImagesCat. No.: HY-103293BCAS No.: 84640-50-6Synonyms: Kallidin (380-389) (human, porcine, bovine) tetraacetateLys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation.
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BKM-570
0 ImagesCat. No.: HY-123560CAS No.: 259885-54-6BKM-570 is a nonpeptide bradykinin antagonist with anticancer effects. BKM-570 can be used in the study of lung cancer, prostate cancer and ovarian cancer.
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Zoliprofen
0 ImagesCat. No.: HY-19646CAS No.: 56355-17-0Synonyms: 480156-SZoliprofen (480156-S), a new non-steroidal anti-inflammatory agent, has potent pain suppressing effect. Zoliprofen has strong antagonistic action against bradykinin, markedly inhibiting all bradykinin-induced edema and pain reactions. Zoliprofen weakly inhibits Arachidonic acid (HY-109590)-induced edema and pain reactions but also inhibits PGE2 synthesis of bovine vesicular gland microsomes.
