Cholecystokinin Receptor
CCK Receptor
Cholecystokinin receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin. Two types of functional membrane receptors, cholecystokinin A receptor (CCK-AR), located mainly on pancreatic acinar cells, and CCK-BR, mostly in the stomach and nervous system tissues, have been identified as the endogenous receptors of CCK. Both have high affinity for the sulfated CCK octapeptide (CCK-8), whereas only the CCK-BR has high affinity for gastrin.
CCK is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, CCK constitutes the classical gut hormone triad. In addition to gallbladder contraction, CCK also regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion. CCK is also a transmitter in central and intestinal neurons.
Cholecystokinin Receptor Isoform Specific Products
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Cholecystokinin Receptor Inhibitors
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Cholecystokinin Receptor Agonists
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Cholecystokinin Receptor Antagonists
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Cholecystokinin Receptor Activators
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Cholecystokinin Receptor Modulator
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Cholecystokinin Receptor Chemical
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Cholecystokinin Receptor Related Products (136)
Related Products (136)
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Cholecystokinin Receptor Isoform Comparison
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LY 202769
0 ImagesCat. No.: HY-125431CAS No.: 139543-40-1
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Lorglumide
0 ImagesCat. No.: HY-B1439CAS No.: 97964-56-2Synonyms: CR-1409Lorglumide (CR-1409) is a potent cholecystokinin (CCK) receptor antagonist. Lorglumide can be used in the research of pancreatic secretion and growth.
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N-acetyl CCK-(26-30) amide
0 ImagesCat. No.: HY-P2165CAS No.: 89911-69-3Synonyms: CCK-(26-30) sulfatedN-acetyl CCK-(26-30) amide (CCK-(26-30) (sulfated)) is a cholecystokinin (CCK) receptor antagonist.
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Cholecystokinin (27-32)-amide
0 ImagesCat. No.: HY-P2638CAS No.: 86367-90-0Synonyms: CCK-27-32-NH2Cholecystokinin (27-32)-amide (CCK-27-32-NH2) is a potent cholecystokinin receptor CCK receptor antagonist.
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RP-69758
0 ImagesCat. No.: HY-116260CAS No.: 138562-23-9RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCKB)/gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCKB over CCKA receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261)-induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research.
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GRP (porcine)
0 ImagesCat. No.: HY-103285CAS No.: 74815-57-9Synonyms: Porcine gastrin-releasing peptide 27GRP (porcine) (Porcine gastrin-releasing peptide 27) is the putative mammalian analog of Bombesin (HY-P0195). GRP (porcine) activates the release of a number of gastroenteropancreatic (GEP) peptides into the peripheral circulation. GRP (porcine) stimulates gastrin release and exocrine pancreatic secretion. GRP (porcine) is a useful marker of neuroendocrine differentiation in many tumors.
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JMV 176
0 ImagesCat. No.: HY-P2121CAS No.: 119068-32-5Jmv 176 is a CCK agonist when first given and becomes a cholecystokinin antagonist after 3-4 hours.
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CHEMBL333994
0 ImagesCat. No.: HY-U00363CAS No.: 167820-10-2Synonyms: FK-480CHEMBL333994 (FK-480) is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis.
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N-Cbz-DL-tryptophan
0 ImagesSynonyms: Z-DL-Trp-OHN-Cbz-DL-tryptophan (Z-DL-Trp-OH) is the enantiomer of Tryptophan (HY-N0623) derivative. N-Cbz-DL-tryptophan is a cholecystokinin receptor antagonist.
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GV-150013
0 ImagesCat. No.: HY-106356CAS No.: 167355-22-8GV-150013 is a selective CCK-B receptor antagonist. GV-150013 has sleep aid effect.
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JMV 167
0 ImagesCat. No.: HY-P1994CAS No.: 120775-49-7JMV 167 is antagonist of peripheral cholecystokinin receptor (CKK), with an IC50 of 500 nM.
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U-67827E
0 ImagesCat. No.: HY-113896CAS No.: 103494-23-1U-67827E is a cholecystokinin (CCK) agonist that decreases food intake over a prolonged period of time in baboons. U-67827E may affect the latency to food by inhibiting the movement of food in the stomach and magnifying a gastric distention signal.
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L-740093
0 ImagesCat. No.: HY-125692CAS No.: 154967-59-6L-740093 is a potent cholecystokinin-B receptor antagonist. L-740093 has excellent central nervous system (CNS) penetration.
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Benzotript
0 ImagesCat. No.: HY-121278CAS No.: 39544-74-6Synonyms: BenzotriptumBenzotript (Benzotriptum) is a cholecystokinin-receptor (CCK) and gastrin receptor antagonist. Benzotript shows antiproliferative effects in human colon carcinoma cell lines.
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L 368935
0 ImagesCat. No.: HY-120862CAS No.: 145878-31-5L 368935 is a cholecystokinin B receptor (CCKB receptor) antagonist. L 368935 is a brain-penetrant and centrally active compound.
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PD 140376
0 ImagesCat. No.: HY-120302CAS No.: 149027-97-4PD 140376 is a potent antagonist for the cholecystokininB/gastrin receptor, with Ki values of 0.18 nM and 0.21 nM in guinea-pig cortex and gastric gland membranes, respectively.
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CI-988
0 ImagesCat. No.: HY-105226CAS No.: 130332-27-3Synonyms: PD134308CI-988 (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC50 of 1.7 nM for mouse cortex CCK2. CI-988 shows >1600-fold selectivity for CCK2 over CCK1 receptor. CI-988 has anxiolytic and anti-tumor effects.
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Itriglumide
0 ImagesCat. No.: HY-106347CAS No.: 201605-51-8Synonyms: CR 2945Itriglumide (CR 2945) is an anthranilic acid derivative. Itriglumide is a potent and selective CCKB receptor antagonist, with an IC50 of 2.3 nM. Itriglumide antagonizes the response to gastrin in a dose-dependent manner with an IC50 of 5.9 nM. Itriglumide shows antisecretory and antiulcer activity.
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BBL454
0 ImagesCat. No.: HY-177509BBL454 (Compound 43) is a Cholecystokinin 2B (CCK2B) receptor agonist. BBL454 induces hyperactivity and improves memory in rat models while it has weak activity on the peripheral CCK2 receptor and no anxiogenic activity. BBL454 increases gastric acid output in anesthetised rat models. BBL454 can be used for diabetes research.
