Cholecystokinin Receptor
CCK Receptor
Cholecystokinin receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin. Two types of functional membrane receptors, cholecystokinin A receptor (CCK-AR), located mainly on pancreatic acinar cells, and CCK-BR, mostly in the stomach and nervous system tissues, have been identified as the endogenous receptors of CCK. Both have high affinity for the sulfated CCK octapeptide (CCK-8), whereas only the CCK-BR has high affinity for gastrin.
CCK is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, CCK constitutes the classical gut hormone triad. In addition to gallbladder contraction, CCK also regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion. CCK is also a transmitter in central and intestinal neurons.
Cholecystokinin Receptor Isoform Specific Products
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Cholecystokinin Receptor Inhibitors
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Cholecystokinin Receptor Agonists
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Cholecystokinin Receptor Antagonists
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Cholecystokinin Receptor Activators
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Cholecystokinin Receptor Modulator
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Cholecystokinin Receptor Chemical
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Cholecystokinin Receptor Controls
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Cholecystokinin Receptor Related Products (136)
Related Products (136)
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Cholecystokinin Receptor Isoform Comparison
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Caerulein, desulfated
0 ImagesCat. No.: HY-P1800CAS No.: 20994-83-6Caerulein, desulfated is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK).
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FPL 14294
0 ImagesCat. No.: HY-105955CAS No.: 154132-95-3Synonyms: ARL 14294FPL 14294 is a intranasally active anorectic agent and a cholecystokinin octapeptide (CCK) analog with enhanced metabolic stability. FPL 14294 induces satiety in many species and can be utilized in relevant research.
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Cholecystokinin (1-21)
0 ImagesCat. No.: HY-P3650CAS No.: 101831-07-6Synonyms: CCK-1-21Cholecystokinin (1-21) (CCK-1-21) is a cholecystokinin (CCK) fragment. Cholecystokinin (1-21) stimulates lipolysis in human adipose tissue.
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CCK (26-31) non-sulfated
0 ImagesCat. No.: HY-P2678CAS No.: 89911-64-8CCK (26-31) (non-sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety. CCK (26-31) is also less active in non-sulfated than in sulfated form.
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LY288513
0 ImagesCat. No.: HY-103357CAS No.: 147523-65-7LY288513 is a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 produces an anxiolytic-like action in mice.
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JMV 179
0 ImagesCat. No.: HY-P1988CAS No.: 119386-87-7JMV 179, a peptide closely related to CCK, is a cholecystokinin receptor (CKK) antagonist, with an IC50 of 30 nM.
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PD-135666
0 ImagesCat. No.: HY-117839CAS No.: 134557-41-8PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models.
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Cholecystokinin-33 (swine)
0 ImagesCat. No.: HY-P3652CAS No.: 67256-27-3Cholecystokinin-33 (swine) is a cholecystokinin (CCK) fragment. Cholecystokinin-33 (swine) can reduce food intake and gallbladder contraction.
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(rac)-CHEMBL333994
0 ImagesCat. No.: HY-U00363ACAS No.: 126149-42-6Synonyms: (rac)-FK-480(rac)-CHEMBL333994 is the racemate of CHEMBL333994 (HY-U00363). CHEMBL333994 is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis.
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JMV 170
0 ImagesCat. No.: HY-P1994ACAS No.: 117829-60-4JMV 170, a CCK derivative, is a selective CCK-B agonist. JMV 170 binds to the CCK-B receptor with a 10-fold higher affinity than to the CCK-A receptor. JMV 170 shows contractile effects on pig smooth muscle cells with an EC50 of 9 pmol/L.
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Asperlicin D
0 ImagesCat. No.: HY-122336CAS No.: 93413-07-1Asperlicin D is a asperlicin productionfrom Aspergillus alliaceus strain (ATCC 20656).
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DA-3934
0 ImagesCat. No.: HY-125610CAS No.: 183176-50-3DA-3934 is a cholecystokinin (CCK)-B receptor antagonist. DA-3934 inhibits Pentagastrin (HY-A0261)-induced gastric acid secretion in rats.
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Proglumide sodium (Standard)
0 ImagesProglumide (sodium) (Standard) is the analytical standard of Proglumide (sodium). This product is intended for research and analytical applications. Proglumide sodium is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium selective blocks CCK’s effects in the central nervous system (CNS). Proglumide sodium has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide sodium also has antiepileptic and antioxidant activities.
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VL-0395
0 ImagesCat. No.: HY-118904CAS No.: 620167-11-5VL-0395 is a CCK1 selective antagonist with IC50 of 0.197 μM for CCK1 in rat pancreatic acinar cells.
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Dexloxiglumide (Standard)
0 ImagesCat. No.: HY-128878RCAS No.: 119817-90-2Dexloxiglumide (Standard) is the analytical standard of Dexloxiglumide. This product is intended for research and analytical applications. Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors.
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KSG-504 anhydrous
0 ImagesCat. No.: HY-129759CAS No.: 137005-17-5KSG-504 (anhydrous) is a CCK receptor antagonist. KSG-504 (anhydrous) inhibits the development of Ethionine-induced acute pancreatitis in rats and facilitates the regeneration of acinar cells.
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Devazepide (Standard)
0 ImagesSynonyms: L-364,718 (Standard); MK-329 (Standard)Devazepide (Standard) is the analytical standard of Devazepide. This product is intended for research and analytical applications. Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.
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PD-149164
0 ImagesCat. No.: HY-123434CAS No.: 181941-32-2PD-149164 is a potent agonist of cholecystokinin B (CCK-B) receptor, with IC50 values of 0.083 nM and 75 nM in binding assay to CCK-B and CCK-A.
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Proglumide (Standard)
0 ImagesProglumide (Standard) is the analytical standard of Proglumide. This product is intended for research and analytical applications. Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
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A-70874
0 ImagesCat. No.: HY-129516CAS No.: 131449-37-1A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor.
