Filovirus
Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).
The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.
Filovirus Isoform Specific Products
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Filovirus Related Products (59)
Related Products (59)
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Filovirus Isoform Comparison
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Vorinostat-d5
0 ImagesSynonyms: SAHA-d5; Suberoylanilide hydroxamic acid-d5Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
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Larcaviximab
0 ImagesCat. No.: HY-P99686CAS No.: 1792982-56-9Synonyms: c4G7-NLarcaviximab (c4G7-N) is an IgG1 kappa chimeric monoclonal antibody against Ebola virus glycoprotein, which is applicable to studies related to Ebola virus infection.
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Cosfroviximab
0 ImagesCat. No.: HY-P99832CAS No.: 1792982-57-0Synonyms: c13C6-FR1Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).
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Chlorphenoxamine hydrochloride
0 ImagesChlorphenoxamine hydrochloride, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine hydrochloride inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine hydrochloride shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease.
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EBOV-IN-2
0 ImagesCat. No.: HY-160877EBOV-IN-2 (Compound 2) is an inhibitor of Ebola virus (EBOV) with IC50 values of 0.37 μM and 2.54 μM against Ebola virus glycoprotein pseudotype virus (pEBOV) and African swine fever virus (ASFV), respectively.
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EBOV/MARV-IN-2
0 ImagesCat. No.: HY-146813CAS No.: 2687244-84-2
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EBOV-IN-8
0 ImagesCat. No.: HY-160883CAS No.: 286854-12-4EBOV-IN-8 (Compound 30) inhibits Ebola pseudotyped virus (pEBOV) infection with an IC50 of 62.1% at 10 μM.
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D011-2120
0 ImagesCat. No.: HY-123266CAS No.: 620931-39-7D011-2120 functions as an antiviral agent by inhibiting microtubule polymerization, disrupting the Golgi complex, and preventing viral trafficking to the plasma membrane during the virus egress process.
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As-358
0 ImagesCat. No.: HY-146883CAS No.: 2222042-47-7As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM.
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ASN03576800
0 ImagesASN03576800 could be a potent inhibitor for Ebola virus matrix protein VP40 in process of viral assembly and budding process. ASN03576800 occupies the RNA binding region of VP40.
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K777 tosylate
0 ImagesCat. No.: HY-119293ACAS No.: 502960-91-0K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively.
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SCR007
0 ImagesCat. No.: HY-178137CAS No.: 2409183-72-6SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.
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EBOV-IN-4
0 ImagesCat. No.: HY-160879CAS No.: 2896193-43-2EBOV-IN-4 (compound 12), a benzothiazepine, is a potent Ebola virus (EBOV) inhibitor with 64.9% inhibitory for EBOV-GP-pseudotype virus (pEBOV) with 10 μM. EBOV-IN-4 is inactive with ASFV.
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SCR005
0 ImagesCat. No.: HY-178135CAS No.: 2409183-70-4SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.
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(-)-Isopinocampheol
0 ImagesCat. No.: HY-W143403ACAS No.: 1196-00-5Synonyms: l-Isopinocampheol(-)-Isopinocampheol (l-Isopinocampheol) is a compound with anti-filovirus activity. Its derivatives inhibit infection by Ebola virus and Marburg virus, possibly through binding to surface glycoproteins. It also has lysosomal affinity.
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As-358 hydrochloride
0 ImagesCat. No.: HY-146883ACAS No.: 2374723-26-7As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.
