Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2769)
Related Products (2769)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Vermistatin
0 ImagesCat. No.: HY-167831CAS No.: 72669-21-7Vermistatin is a metabolite of the fungal strain Guignardia that has cytotoxic and antifungal activity.
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Bromuconazole
0 ImagesCat. No.: HY-W715812CAS No.: 116255-48-2Bromuconazole is a triazole fungicide with oral efficacy and blood-brain barrier permeability. Bromuconazole protects crops from various fungal contaminations. Bromuconazole exhibits cytotoxicity against a variety of cancer cells, induces G0/G1 cell cycle arrest and inhibits DNA synthesis in cancer cells, and triggers cytoskeletal structural disorder, genotoxic damage, apoptotic (apoptosis) cell death, and mitochondrial membrane depolarization. Bromuconazole activates caspase-3, induces excessive production of ROS, p53 and Bax, lipid peroxidation, increased activities of SOD and CAT, and downregulates Bcl-2. By upregulating p-ERK1/2 and p-JNK, Bromuconazole disrupts the MAPK signaling pathway, impairs the cellular stress response of human trophoblast cells and endometrial cells, and damages the implantation process. Bromuconazole is applicable to research related to glioma, colon cancer, reproductive injury (implantation dysfunction), and cardiac dysfunction.
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Sotolone-d2
0 ImagesCat. No.: HY-W021008SSynonyms: Dimethylhydroxyfuranone-d2Sotolone-d2 (Dimethylhydroxyfuranone-d2) is deuterated labeled Sotolone. Sotolone is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.
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Coniferyl alcohol (Standard)
0 ImagesConiferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation.
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Cyclothiazomycin
0 ImagesCat. No.: HY-N5185CAS No.: 133352-26-8Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity.
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CYP51-IN-10
0 ImagesCat. No.: HY-136760CAS No.: 1155361-08-2CYP51-IN-10 is cytochrome P450 14a-demethylase (CYP51) inhibitor with antifungal activity. CYP51-IN-10 can be used for the research of fungal infection.
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Cladospolide D
0 ImagesCat. No.: HY-N14669CAS No.: 371229-61-7Cladospolide D is found in the strain of Cladosporium sp. FT-0012. Cladospolide D has the activity against part of fungi.
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Benanomicin B
0 ImagesCat. No.: HY-N15184CAS No.: 116249-66-2Synonyms: Pradimicin CBenanomicin B (Pradimicin C) is an antifungal antibiotic that also has antibacterial activity against two Gram-positive bacteria: Micrococcus luteus and Corynebacterium bovis.
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JSZ16
0 ImagesCat. No.: HY-175722JSZ16 is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 30.3 μM. JSZ16 has potent broad-spectrum fungicidal activity, such as Sclerotinia sclerotiorum, Botrytis cinerea and Colletotrichum fragariae, with an EC50 of 4.4 mg/L for Sclerotinia sclerotiorum. JSZ16 influences the cell membrane permeability of pathogenic fungi. JSZ16 can be used for the development of fungicide.
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Ethylparaben-d5
0 ImagesCat. No.: HY-W701251CAS No.: 126070-21-1Synonyms: Ethyl parahydroxybenzoate-d5; Ethyl 4-hydroxybenzoate-d5Ethylparaben-d5 (Ethyl parahydroxybenzoate-d5) is deuterium labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive.
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Clavamycin C
0 ImagesCat. No.: HY-N13997CAS No.: 103059-94-5Clavamycin C has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
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Haloprogin (Standard)
0 ImagesHaloprogin (Standard) is the analytical standard of Haloprogin. This product is intended for research and analytical applications. Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria.
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DHFR-IN-25
0 ImagesCat. No.: HY-179493CAS No.: 3002069-20-4DHFR-IN-25 (Compound N2) is a type of inhibitor of dihydrofolate reductase (DHFR). DHFR-IN-25 is a broad-spectrum and highly effective antibacterial agent, particularly showing significant effects on Candida albicans and Staphylococcus aureus. DHFR-IN-25 can be used for the study of local anti-infection.
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Decamethoxine (Standard)
0 ImagesCat. No.: HY-108004RCAS No.: 38146-42-8Synonyms: Septefril (Standard); Decametoxin (Standard)Decamethoxine (Standard) is the analytical standard of Decamethoxine (HY-108004). This product is intended for research and analytical applications. Decamethoxine (Septefril) is a cationic gemini surfactant. Decamethoxine exhibits strong bactericidal and fungicidal effects. Decamethoxine modifies the permeability of the microbial cell membrane, resulting in the destruction and death of diverse microorganisms.
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Triflumizole (Standard)
0 ImagesCat. No.: HY-W020777RCAS No.: 68694-11-1Triflumizole (Standard) is the analytical standard of Triflumizole. This product is intended for research and analytical applications. Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops.
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Serratamolide
0 ImagesSerratamolide is a depsipeptide antibiotic. Serratamolide has anti-Gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak.
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Cispentacin
0 ImagesCat. No.: HY-W089091CAS No.: 122672-46-2Cispentacin has anti-candida and other fungi activity, and has no toxicity at 1g/kg.
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Prumycin dihydrochloride
0 ImagesCat. No.: HY-129548ACAS No.: 57420-47-0Prumycin dihydrochloride is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin dihydrochloride significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin dihydrochloride did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca.
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Antibiotic WB
0 ImagesCat. No.: HY-N12913CAS No.: 247919-66-0Antibiotic WB is an antibioticwith antifungal activity and can be isolated from the soil fungus strain 38.
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Antifungal agent 142
0 ImagesCat. No.: HY-180144Antifungal agent 142 (Compound B1) is a broad-spectrum antifungal agent. Antifungal agent 142 can enhance cell membrane permeability and disrupt membrane integrity, hindering normal mycelial growth. Antifungal agent 142 can be used as agricultural fungicide.
