GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Modulators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (789)
Related Products (789)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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Isohyenanchin
0 ImagesCat. No.: HY-N3478CAS No.: 19417-00-6Synonyms: HydroxycoriatinIsohyenanchin (Hydroxycoriatin) is an RDLac homo-oligomers antagonist. Isohyenanchin also is a weak antagonist of ionotropic GABA receptors.
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(S)-3C4HPG
0 ImagesCat. No.: HY-100842ACAS No.: 55136-48-6(S)-3C4HPG is a metabotropic glutamate receptor antagonist, demonstrating significant potential in modulating neuronal excitability and influencing synaptic transmission.
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GABAA receptor agent 5
0 ImagesCat. No.: HY-145257CAS No.: 1808389-92-5GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability.
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Pipazethate hydrochloride
0 ImagesCat. No.: HY-W742300CAS No.: 6056-11-7Synonyms: SKF 70230A hydrochloride; SQ 15874 hydrochloride; Pipazetate hydrochloridePipazethate (SKF 70230A; SQ 15874) hydrochloride is a potent GABA antagonist. Pipazethate hydrochloride shows antitussive activity and can be used in research in cough suppressant .
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Sarmazenil
0 ImagesCat. No.: HY-100248CAS No.: 78771-13-8Synonyms: Ro 15-3505Sarmazenil is a benzodiazepine receptor antagonist.
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Org20599
0 ImagesCat. No.: HY-103498CAS No.: 156685-94-8Org20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABAA receptor with an EC50 of 1.1 μM.
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Broflanilide (Standard)
0 ImagesBroflanilide (Standard) is the analytical standard of Broflanilide. This product is intended for research and analytical applications. Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.
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GABA receptor Antagonist 1
0 ImagesCat. No.: HY-156339GABA receptor Antagonist 1 (compound 7w) inhibits Px RDL1 GABAR with an IC50 value of 7.08 nmol/L. GABA receptor Antagonist 1 shows insecticide activity against P. xylostella, S. frugiperda, S. exigua, and S. litura, with LC50 of 0.09, 0.84, 0.87, and 0.68 mg/L respectively. GABA receptor Antagonist 1 shows a medium toxicity to honeybee (48 h, ID50 = 2.22 μg/adult), and low toxicity to zebrafish (LC50: 42.4 mg/L).
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GABA receptor antagonist 3
0 ImagesCat. No.: HY-184987CAS No.: 3106082-79-2GABA receptor antagonist 3 is a GABA receptor antagonist with insecticidal activity. GABA receptor antagonist 3 binds deeply inside the receptor pore, forms stable interactions with key residues to disrupt channel gating, and inhibits GABA-induced currents. GABA receptor antagonist 3 exhibits insecticidal activity against Spodoptera frugiperda. GABA receptor antagonist 3 can be used in pest control research.
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LAU159
0 ImagesCat. No.: HY-112426CAS No.: 2055050-87-6LAU159 is a functionally selective positive modulator of α1β3 GABA(A) receptor with an EC50 of 2.2 μM.
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Gidazepam-d5
0 ImagesCat. No.: HY-U00315SSynonyms: Gidasepam-d5; Hidazepam-d5; Hydazepam-d5Gidazepam-d5 is a deuterium labeled Gidazepam. Gidazepam is an agonist of GABA receptor channels (GABA RCs), and has anticonvulsant effect.
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ZK 93426 hydrochloride
0 ImagesCat. No.: HY-103499CAS No.: 1216792-30-1ZK 93426 (hydrochloride) is a benzodiazepine antagonist. ZK 93426 (hydrochloride) can be used for the research of neurological disease.
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Ro 14-7437
0 ImagesCat. No.: HY-116859CAS No.: 78756-03-3Ro 14-7437 is a potent and selective potentiating antagonist of Midazolam.
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Gabazine free base
0 ImagesCat. No.: HY-117256CAS No.: 105538-73-6Synonyms: SR95531 free baseGabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of 0.2 μM for GABA receptor.
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Etbicyphat
0 ImagesEtbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors.
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CGP36216
0 ImagesCat. No.: HY-103518CAS No.: 123691-29-2CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a Ki value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders.
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Furosemide solution
0 ImagesCat. No.: HY-FLB0135CAS No.: 54-31-9Furosemide solution is mainly composed of Furosemide (HY-B0135). Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.
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CGP 56999
0 ImagesCat. No.: HY-123222CAS No.: 153994-97-9CGP 56999 is a potent antagonist GABA(B) receptor, with the IC50 of 0.002 μM. CGP 56999 increased the levels of BDNF mRNA in the brain in vivo and in vitro.
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GABAA receptor agent 4
0 ImagesCat. No.: HY-145256CAS No.: 2035203-91-7GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential.
