1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. GABAA receptor agent 4

GABAA receptor agent 4 

Cat. No.: HY-145256
Handling Instructions

GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential.

For research use only. We do not sell to patients.

GABAA receptor agent 4 Chemical Structure

GABAA receptor agent 4 Chemical Structure

CAS No. : 2035203-91-7

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Description

GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential[1].

IC50 & Target

Ki: 0.18 µM (γ-GABAAR)[1]

In Vitro

GABAA receptor agent 4 (compound 1e) shows antagonist activity with IC50s of 4.95, 0.195, 0.250, 1.95, 2.18, 7.56, 0.56, 0.54 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].
GABAA receptor agent 4 (50 µM; 96 h) rescues inhibition of proliferation induced by alprazolam in both human PBMC and mouse splenocytes populations with minimal cell toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

272.39

Formula

C17H24N2O

CAS No.
SMILES

O=C(N1CCC2(CC1)CCNCC2)C3=CC=CC(C)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GABAA receptor agent 4
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HY-145256
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