GABAA receptor agent 4
GABAA receptor agent 4 (compound 1e) is a potent γ-GABAAR antagonist with an Ki of 0.18 µM. GABAA receptor agent 4 efficiently rescues inhibition of T cell proliferation. GABAA receptor agent 4 has the immunomodulatory potential.
For research use only. We do not sell to patients.
- CAS No.: 2035203-91-7
- Formula: C17H24N2O
- Molecular Weight:272.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 0.18 µM (γ-GABAAR)[1]
GABAA receptor agent 4 (compound 1e) shows antagonist activity with IC50s of 4.95, 0.195, 0.250, 1.95, 2.18, 7.56, 0.56, 0.54 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].
GABAA receptor agent 4 (50 µM; 96 h) rescues inhibition of proliferation induced by alprazolam in both human PBMC and mouse splenocytes populations with minimal cell toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2035203-91-7
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Molecular Weight 272.39
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Formula C17H24N2O
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SMILES
O=C(N1CCC2(CC1)CCNCC2)C3=CC=CC(C)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GABAA receptor agent 4 Related Classifications
HY-145256 Related Classifications
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