GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Modulators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (789)
Related Products (789)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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GABAB receptor antagonist 4
0 ImagesCat. No.: HY-174147CAS No.: 91981-93-0GABAB receptor antagonist 4 (Compound 28) is a GABAB receptor antagonist. GABAB receptor antagonist 4 can inhibit GABA-induced G protein activation. GABAB receptor antagonist 4 competitively binds to the orthosteric site of GABAB receptor. GABAB receptor antagonist 4 can be used to study GABAB receptor-related neurological diseases.
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Dehydroepiandrosterone sulfate sodium (Standard)
0 ImagesSynonyms: DHEA sulfate sodium (Standard); Prasterone sulfate sodium (Standard)Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt (Standard) is the analytical standard of Dehydroepiandrosterone sulfate sodium salt (HY-B0765). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality.
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GABA receptor antagonist 2
0 ImagesCat. No.: HY-175190CAS No.: 2922115-20-4GABA receptor antagonist 2 (Compound IId) is a GABA receptor antagonist with a LC50 of 0.0735 μg/mL for Plutella xylostella (P. xylostella). GABA receptor antagonist 2 has significant insecticidal activities against P. xylostella and its resistant strain, and Spodoptera frugiperda, and Chilo suppressalis. GABA receptor antagonist 2 binds the GABA receptor at the site of Drosophila RdlG335. GABA receptor antagonist 2 can be used to manage resistant pest populations.
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Bicuculline methobromide
0 ImagesCat. No.: HY-100783BCAS No.: 66016-70-4Synonyms: (+)-Bicuculline methobromideBicuculline methobromide is a selective GABAA Receptor antagonist with an IC50 value of 3 μM. Bicuculline methobromide induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methobromide can be used in studies of epilepsy and other related psychiatric disorders.
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17-PA
0 ImagesCat. No.: HY-103495CAS No.: 694438-95-417-PA is a selective antagonist of neurosteroid potentiation and direct gating of GABAA receptors.
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p-Hydroxybenzaldehyde-13C
0 ImagesCat. No.: HY-Y0313S1CAS No.: 152404-52-9p-Hydroxybenzaldehyde-13C is the 13C-labeled p-Hydroxybenzaldehyde. p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
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R 29676 (Standard)
0 ImagesR 29676 is a neuroleptic agent and inhibits sodium-dependent GABA binding (GABA uptake).
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Furosemide hydrochloride
0 ImagesCat. No.: HY-B0135BCAS No.: 42461-27-8Furosemide hydrochloride is an orally active GABAA receptor antagonist. Furosemide hydrochloride inhibits carbonic anhydrase, the sodium-chloride cotransporter, sodium reabsorption, tubuloglomerular feedback, and GABA-induced chloride flux. Furosemide hydrochloride can be used as a diuretic reagent. Furosemide hydrochloride is applied in the research of hepatic necrosis, sepsis-associated acute kidney injury, hypoalbuminemia-related fluid retention, and congestive heart failure.
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Gabazine (Standard)
0 ImagesSynonyms: SR95531 (Standard)Gabazine (Standard) is the analytical standard of Gabazine. This product is intended for research and analytical applications. Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor.
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Picrotoxinin (Standard)
0 ImagesCat. No.: HY-B1494RCAS No.: 17617-45-7Picrotoxinin (Standard) is the analytical standard of Picrotoxinin. This product is intended for research and analytical applications. Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC50 of 1.15 μM.
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Radequinil (Standard)
0 ImagesCat. No.: HY-106025RCAS No.: 219846-31-8Synonyms: AC-3933 (Standard)Radequinil (Standard) is the analytical standard of Radequinil (HY-106025). This product is intended for research and analytical applications. Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively.
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Epiallopregnanolone-d5
0 ImagesCat. No.: HY-124463S1Synonyms: 5α,3β-THDOC-d5Epiallopregnanolone-d5 (5α,3β-THDOC-d5) is deuterium labeled Epiallopregnanolone. Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.
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Golexanolone
0 ImagesCat. No.: HY-120276CAS No.: 2089238-18-4Synonyms: GR3027Golexanolone is a GABAA receptor modulating steroid antagonist. Golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats.
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S-8510 free base
0 ImagesCat. No.: HY-114685CAS No.: 151224-83-8Synonyms: SB-737552 free baseS-8510 free base is an inverse Benzodiazepine (BDZ) receptor agonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
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Carbiphene
0 ImagesCat. No.: HY-105567CAS No.: 15687-16-8Carbiphene is a GABAA receptor allosteric modulator. Carbiphene inhibits [35S] TBPS binding and enhances [3H] muscimol binding on rat forebrain membranes, acting on specific GABAA receptor subsets. Carbiphene can be used in research related to schizophrenia.
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(iodo-125)-CGP 71872
0 ImagesCat. No.: HY-11065ACAS No.: 200402-51-3(iodo-125)-CGP 71872 is a iodo-125-labeled CGP 71872 (GABABR1 receptor agonist),containing an azido group that can be photoactivated,and can be used to characterize GABAB receptors.
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GMQ
0 ImagesGMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion.
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GABAB receptor antagonist 3
0 ImagesCat. No.: HY-160105CAS No.: 160415-40-7GABAB receptor antagonist 3 (example 3) is a antagonist of GABAB receptor.
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Bemegride (Standard)
0 ImagesSynonyms: 3-Ethyl-3-methylglutarimide (Standard); Bemegrid (Standard)Bemegride (Standard) is the analytical standard of Bemegride. This product is intended for research and analytical applications. Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.
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RO 4938581 (Standard)
0 ImagesCat. No.: HY-107489RCAS No.: 883093-10-5RO 4938581 (Standard) is the analytical standard of RO 4938581 (HY-107489). This product is intended for research and analytical applications. RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
