716-11-0
Chemical Structure
GMQ
Synonym(s): 2-Guanidine-4-methylquinazoline
- CAS No.: 716-11-0
- Formula:C10H11N5
- Molecular Weight:201.23
IUPAC Name: 1-(4-methylquinazolin-2-yl)guanidine
InChIKey: ONQKSKDLYYDFLL-UHFFFAOYSA-N
SMILES: NC(NC1=NC(C)=C2C=CC=CC2=N1)=N
Biological Activity: GMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion[1].
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GMQ | GMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion. | |||||||||||||||||||||
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Keywords
