2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GMQ

GMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion.

For research use only. We do not sell to patients.

GMQ

GMQ Chemical Structure

CAS No. : 716-11-0

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Description

GMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion[1].

Molecular Weight

201.23

Formula

C10H11N5
CAS No.
SMILES

NC(NC1=NC(C)=C2C=CC=CC2=N1)=N
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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GMQ Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GMQ716-11-02-Guanidine-4-methylquinazolineGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorHEK293Tmiceanti-histamineInhibitorinhibitorinhibit

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