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Cat. No.: HY-107489R

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RO 4938581 (Standard)

RO 4938581 (Standard) is the analytical standard of RO 4938581 (HY-107489). This product is intended for research and analytical applications. RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a K_i of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K_i, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.

For research use only. We do not sell to patients.

CAS No.: 883093-10-5
Formula: C₁₃H₈BrF₂N₅
Molecular Weight:352.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RO 4938581 (Standard) Chemical Structure

CAS No.: 883093-10-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

Ki: 4.6 nM (GABA_A α5β3γ2a), 174 nM (GABA_A α1β3γ2a), 185 nM (GABA_A α2β3γ2a), 80 nM (GABA_A α3β3γ2a)^[1]

Chemical Information

CAS No. 883093-10-5
Molecular Weight 352.14
Formula C₁₃H₈BrF₂N₅
SMILES

FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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