GABA Receptor
Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor
GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.
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GABA Receptor Inhibitors
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GABA Receptor Agonists
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GABA Receptor Antagonists
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GABA Receptor Activators
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GABA Receptor Modulators
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GABA Receptor Controls
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GABA Receptor Ligands
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GABA Receptor Related Products (791)
Related Products (791)
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Antibodies (14)
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Related Compound Screening Libraries (1)
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CGP 62349
0 ImagesCat. No.: HY-120192CAS No.: 187608-26-0CGP 62349 is a selective and orally active GABAB receptor antagonist that improves cognitive performance in multiple learning paradigms.
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CGP 36742 (Standard)
0 ImagesCat. No.: HY-121599RCAS No.: 123690-78-8Synonyms: SGS-742 (Standard)CGP 36742 (Standard) is the analytical standard of CGP 36742. This product is intended for research and analytical applications. CGP 36742 (SGS-742) is an orally active and selective antagonist of GABAB receptor (IC50 = 36 µM). CGP 36742 is a brain-penetrant compound and improves cognitive performances. CGP 36742 can be used for depression study.
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Ro15-4513 (Standard)
0 ImagesCat. No.: HY-103476RCAS No.: 91917-65-6Ro15-4513 (Standard) is the analytical standard of Ro15-4513. This product is intended for research and analytical applications. Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR). Ro15-4513 is a potent ethanol antagonist. Ro15-4513 has anti-anxiety effect. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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CGS-9895
0 ImagesCat. No.: HY-129090CAS No.: 77779-50-1CGS-9895 is a GABA antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors.
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Thiocolchicoside (Standard)
0 ImagesThiocolchicoside (Standard) is the analytical standard of Thiocolchicoside. This product is intended for research and analytical applications. Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties.
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CGP52432 (Standard)
0 ImagesCat. No.: HY-103531RCAS No.: 139667-74-6
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Chrodrimanin B
0 ImagesCat. No.: HY-N8472CAS No.: 132196-54-4Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on?B.?mori GABAR RDL with an IC50?of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50?of 1.66 nM.?Chrodrimanin B, a meroterpenoid, shows insecticidal activity.
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Flumazenil (Standard)
0 ImagesSynonyms: Ro 15-1788 (Standard)Flumazenil (Standard) is the analytical standard of Flumazenil. This product is intended for research and analytical applications. Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
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CGP35348 (Standard)
0 ImagesCat. No.: HY-103530RCAS No.: 123690-79-9CGP35348 (Standard) is the analytical standard of CGP35348. This product is intended for research and analytical applications. CGP 35348?is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM.?CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.
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Saclofen (Standard)
0 ImagesCat. No.: HY-100813RCAS No.: 125464-42-8Saclofen (Standard) is the analytical standard of Saclofen.
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Fluxametamide (Standard)
0 ImagesCat. No.: HY-108690RCAS No.: 928783-29-3Fluxametamide (Standard) is the analytical standard of Fluxametamide (HY-108690). This product is intended for research and analytical applications. Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls.
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SKF 10810
0 ImagesCat. No.: HY-171471CAS No.: 22196-65-2SKF 10810 is a GABAA receptor antagonist with an EC50 of 4.3 μM. By blocking GABAergic inhibition of the brain's reward pathways, SKF 10810 may exert antidepressant effects. SKF 10810 can be used for research in neurological disorders.
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NCS-382
0 ImagesCat. No.: HY-101207CAS No.: 520505-01-5NCS-382 is a potent GABA receptor antagonist and also a GHBR receptor antagonist. NCS-382 has anticonvulsant and antisedative activity. NCS-382 is used in the related research of hereditary nervous system diseases.
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Pitrazepin
0 ImagesCat. No.: HY-183910CAS No.: 90685-01-1Pitrazepin is a GABAA receptor antagonist and glycine receptor antagonist. Pitrazepin blocks synaptic GABA action, induces neuronal bursting and reduces inhibitory postsynaptic potentials. Pitrazepin can be used in research on depression and psychosis.
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Tigolaner (Standard)
0 ImagesCat. No.: HY-109077RCAS No.: 1621436-41-6Synonyms: BAY-1272858 (Standard)
