1. Membrane Transporter/Ion Channel
  2. Chloride Channel

Fluxametamide 

Cat. No.: HY-108690
Handling Instructions

Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95  nM and 225  nM for M. domestica GABACls and GluCls.

For research use only. We do not sell to patients.

Fluxametamide Chemical Structure

Fluxametamide Chemical Structure

CAS No. : 928783-29-3

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  • Biological Activity

  • Technical Information

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Description

Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC50 of 1.95  nM and 225  nM for M. domestica GABACls and GluCls.

IC50 & Target

IC50: 1.95  nM (M. domestica GABACls), 225  nM (M. domestica GluCls)[1]

In Vitro

Fluxametamide is an antagonist of GABA- and glutamate-gated chloride channels, dose-dependently inhibits currents induced by GABA and glutamate in M. domestica GABACls and GluCls, with IC50 values of 1.95 (1.18−3.21) nM and 225 (137−372) nM, respectively, and displays potent antagonistic activity against T. urticae GABACls with an IC50 of 0.219 (0.127 − 0.381) nM. Fluxametamide inhibits GABA responses in the wild-type L. striatellus GABACls with IC50 values of 1.40 (0.57 − 3.29) nM; in the A2′N mutant GABACls, the IC50 value is 3.51 (2.17 − 5.69)  nM. Moreover, Fluxametamide scarcely inhibits GABA (EC50)-induced currents in rat GABACls at 10  μM and with no inhibition on glycine (EC50)-induced current in human α1 GlyCls at tested concentrations[1].

In Vivo

Fluxametamide shows significant insecticidal activity with an LD50 (LD95) value of 12.9 ± 4.9 ng/fly (38.7 ± 6.3  ng/fly)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1085 mL 10.5427 mL 21.0855 mL
5 mM 0.4217 mL 2.1085 mL 4.2171 mL
10 mM 0.2109 mL 1.0543 mL 2.1085 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

474.26

Formula

C₂₀H₁₆Cl₂F₃N₃O₃

CAS No.

928783-29-3

SMILES

FC(F)(C1(C2=CC(Cl)=CC(Cl)=C2)CC(C3=CC(C)=C(C(N/C=N/OC)=O)C=C3)=NO1)F

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Fluxametamide
Cat. No.:
HY-108690
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Fluxametamide

Cat. No.: HY-108690