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Cat. No.: HY-184987

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GABA receptor antagonist 3

GABA receptor antagonist 3 is a GABA receptor antagonist with insecticidal activity. GABA receptor antagonist 3 binds deeply inside the receptor pore, forms stable interactions with key residues to disrupt channel gating, and inhibits GABA-induced currents. GABA receptor antagonist 3 exhibits insecticidal activity against Spodoptera frugiperda. GABA receptor antagonist 3 can be used in pest control research.

For research use only. We do not sell to patients.

CAS No.: 3106082-79-2
Formula: C₂₂H₁₆Cl₂F₄N₄O₃
Molecular Weight:531.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GABA receptor antagonist 3 Chemical Structure

CAS No.: 3106082-79-2

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

In Vitro

GABA receptor antagonist 3 (compound H10) inhibits GABA-induced currents generated by heterologously expressed PxRDL1 homopentameric receptors in Xenopus laevis oocytes, with a corresponding IC₅₀ = 0.91 nM, and its inhibitory activity is significantly superior to that of Fluxametamide (HY-108690)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GABA receptor antagonist 3 (compound H10) exhibits excellent insecticidal activity against P. xylostella, with an LC₅₀ of 0.21 mg/L^[1].
GABA receptor antagonist 3 exhibits potent insecticidal activity against S. frugiperda, with an LC₅₀ of 1.88 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3106082-79-2
Molecular Weight 531.29
Formula C₂₂H₁₆Cl₂F₄N₄O₃
SMILES

CC1=C(C(NCC2=NOC(C)=N2)=O)C=CC(C3=NOC(C4=CC(Cl)=C(F)C(Cl)=C4)(C(F)(F)F)C3)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen S, et al. Design, Synthesis, and Insecticidal Potential of 1,2,4-Oxadiazole-Fused Isoxazoline Derivatives as GABA Receptor Antagonists. Journal of agricultural and food chemistry. 2026 Jul 15;74(27):20900-20910. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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