Glycosidase Substrate

HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase). HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase (GGT) probe gGlu-2OMe SiR600 (HY-D3188), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer, fibroadenoma, phyllodes tumor and various types of papilloma.

Chlorophenol Red is a sulfonephthalein pH indicator dye and chromogenic beta-galactosidase substrate. Chlorophenol Red enables the detection of coliform bacteria through β-galactosidase activity. Chlorophenol Red can be used in research on drinking water quality monitoring.

Phenyl-α-D-mannopyranoside is a Concanavalin A inhibitor. Phenyl-α-D-mannopyranoside blocks Histamine (HY-B1204) release induced by Concanavalin A (HY-P2149) . Phenyl-α-D-mannopyranoside acts as a donor in the transfer reaction catalyzed by α-D-mannosidase, forming isomeric mannosides with D-ribose as the acceptor.

Chlorophenol Red sodium is a sulfonephthalein pH indicator dye and chromogenic beta-galactosidase substrate. Chlorophenol Red sodium enables the detection of coliform bacteria through β-galactosidase activity. Chlorophenol Red sodium can be used in research on drinking water quality monitoring.

Maltose solution, 20% in H₂O is a 20% aqueous maltose solution. Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.