Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
(3)
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Ligands for Target Protein for PROTAC Chemicals
(6)
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Ligands for Target Protein for PROTAC Degrader
(1)
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Ligands for Target Protein for PROTAC Controls
(9)
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Ligands for Target Protein for PROTAC Ligands
(12)
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Ligands for Target Protein for PROTAC Related Products (688)
Related Products (688)
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Related Compound Screening Libraries (1)
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(4R,5S)-RG7112D
0 ImagesCat. No.: HY-158685A(4R,5S)-RG7112D is an isomer of RG7112D (HY-158685). The IC50 values of RG7112D for inhibiting MDM2-p53 and VHL-HIF1α are 11 nM and >10000 nM, respectively. (4R,5S)-RG7112D can be used in studies related to PROTAC synthesis, for example, serving as the target protein ligand of (4R,5S)-YX-02-030 (HY-158684A).
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SOS1 Ligand intermediate-5
0 ImagesCat. No.: HY-161655CAS No.: 3043923-70-9SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654).
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AR ligand-29
0 ImagesCat. No.: HY-168296CAS No.: 88378-55-6AR ligand-29 is the target protein ligand of PROTAC VinclozolinM2-2204 (HY-161741), which can be used for cancer research.
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TEAD ligand 3
0 ImagesCat. No.: HY-181538TEAD ligand 3 (compound S20) is a TEAD ligand. As a target protein ligand, TEAD ligand 3 can be used in the synthesis of PROTAC TEAD1/IAP degrader-2 (HY-181537).
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SMARCA2/4-ligand-2
0 ImagesCat. No.: HY-159545CAS No.: 2568281-88-7SMARCA2/4-ligand-2 is a ligand for target protein for pROTAC.
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BRD4 ligand 10
0 ImagesCat. No.: HY-185884CAS No.: 2086299-38-7BRD4 ligand 10 is a PROTAC target protein ligand. BRD4 ligand 10 can be used to synthesize PROTAC BRD4 Degrader-49 (HY-185854).
