Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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(5Z,13E)-9Alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate
0 ImagesCat. No.: HY-180616Synonyms: 15-Dehydro-prostaglandin D2(5Z,13E)-9Alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate (15-Dehydro-prostaglandin D2) is a class of eicosanoids.
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3α,7α-Dihydroxy-24-oxo-5β-cholestan-26-oyl-CoA
0 ImagesCat. No.: HY-180592CAS No.: 344920-81-63α,7α-Dihydroxy-24-oxo-5β-cholestan-26-oyl-CoA is a coenzyme A (CoA) ester is involved in bile acid biosynthesis.
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2’,3’,5’-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine
0 ImagesCat. No.: HY-152998CAS No.: 1613530-52-12’,3’,5’-Tri-O-acetyl-5-methoxycarbonylmethyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Fluoro-4’-C-methyluridine
0 ImagesCat. No.: HY-152522CAS No.: 660845-69-2
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6-Ethoxy-9-beta-D-(2-C-methyl-ribofuranosyl)purine
0 ImagesCat. No.: HY-152655CAS No.: 848750-87-86-Ethoxy-9-beta-D-(2-C-methyl-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine
0 ImagesCat. No.: HY-154283CAS No.: 2389988-53-62-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2-Amino-7-propargyl-7,8-dihydro-8-oxo-9-(beta-D-xylofuranosyl)purine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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3’-Azido-3’-deoxy-5-methoxyuridine
0 ImagesCat. No.: HY-152713CAS No.: 2095417-70-03’-Azido-3’-deoxy-5-methoxyuridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-methoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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5’-O-(4,4’-Dimethoxytrityl)-2’-O-t-butyldimethylsilyl adenosine
0 ImagesCat. No.: HY-W560807CAS No.: 81794-13-05’-O-(4,4’-Dimethoxytrityl)-2’-O-t-butyldimethylsilyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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N4-Benzoyl-5-methyl-2’-O,4’-C-methylenecytidine
0 ImagesCat. No.: HY-154077CAS No.: 206055-81-4
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N6-Dimethylaminomethylidene isoguanosine
0 ImagesCat. No.: HY-154722CAS No.: 156706-72-8N6-Dimethylaminomethylidene isoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-O-(2-Methoxyethyl)-2-thiouridine
0 ImagesCat. No.: HY-152482CAS No.: 647839-20-13’-O-(2-Methoxyethyl)-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
0 ImagesCat. No.: HY-154507CAS No.: 131474-72-1N2-Phenoxyacetyl-3′,5′-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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Indolylmethyl-desulfoglucosinolate
0 ImagesCat. No.: HY-N17703CAS No.: 43110-92-5Indolylmethyl-desulfoglucosinolate is a glucosinolate metabolism.
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2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine
0 ImagesCat. No.: HY-154403CAS No.: 2095417-08-42’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-3’-fluoro-xyloguanosine
0 ImagesCat. No.: HY-152584CAS No.: 125291-15-83’-Deoxy-3’-fluoro-xyloguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-5-methycytidine
0 Images3’-Deoxy-5-methycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7-TFA-ap-7-Deaza-ddG
0 ImagesCat. No.: HY-138587CAS No.: 114748-68-47-TFA-ap-7-Deaza-ddG (compound 19d, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.
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2-Amino-ATP tetrasodium
0 ImagesCat. No.: HY-131787A2-Amino-ATP tetrasodium is an ATP substitute produced by inserting an amino acid at the C2 position of ATP.
