Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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2-Chloro-2’-β-C-methyl-6-N,N-dimethyladenosine
0 ImagesCat. No.: HY-152711CAS No.: 2095417-43-72-Chloro-2’-β-C-methyl-6-N,N-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3′-C-Methylguanosine
0 ImagesCat. No.: HY-152610CAS No.: 115303-89-43′-C-Methylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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3’-Deoxy-2’,5’-di-O-acetyl-8-hydroxyguanosine
0 ImagesCat. No.: HY-154454CAS No.: 2389988-72-93’-Deoxy-2’,5’-di-O-acetyl-8-hydroxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-O-Phthalimidopropyl cytidine
0 ImagesCat. No.: HY-154528CAS No.: 165381-50-02’-O-Phthalimidopropyl cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Methoxyestradiol-17beta 3-sulfate
0 ImagesCat. No.: HY-180682CAS No.: 31635-11-72-Methoxyestradiol-17beta 3-sulfate is a nucleoside metabolite.
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5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine
0 ImagesCat. No.: HY-154042CAS No.: 2305415-75-05’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine
0 ImagesCat. No.: HY-154478CAS No.: 74925-81-83’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5'-Homocytidine
0 ImagesCat. No.: HY-154668CAS No.: 55085-34-25'- Homocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
0 ImagesCat. No.: HY-180755CAS No.: 75222-07-0cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol (compound VII) is a metabolite of the dioxygenolytic pathway for initial catabolism of Hydrocinnamic acid (3-phenylpropionic acid) (HY-Y1088).
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1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose
0 ImagesCat. No.: HY-154362CAS No.: 1612192-28-51,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Bis(glutathionyl)spermine
0 ImagesCat. No.: HY-180772CAS No.: 610310-45-7Bis(glutathionyl)spermine is a glutathione-spermidine conjugate.
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(3S)-2,3-Oxidosqualene
0 ImagesCat. No.: HY-W743885CAS No.: 54910-48-4Synonyms: (3S)-Squalene oxide; (S)-2,3-Epoxysqualene(3S)-2,3-Oxidosqualene ((3S)-Squalene oxide; (S)-2,3-Epoxysqualene) is a nucleoside metabolite.
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2'-Deoxyinosine 5'-diphosphate
0 ImagesCat. No.: HY-W394128CAS No.: 26575-15-5Synonyms: dIDP2'-Deoxyinosine 5'-diphosphate (dIDP) is a nucleoside metabolite.
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5-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine
0 ImagesCat. No.: HY-152705CAS No.: 69123-93-9
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S-Gem
0 ImagesCat. No.: HY-154842CAS No.: 2169925-98-6S-Gem is a TrxR-dependent prodrug of Gemcitabine (HY-17026) and selectively activated by TrxR. S-Gem shows less cytotoxicity compared to Gemcitabine.
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2’,3’-Bis-O-(t-butyldimethylsilyl)-N1-methylpseudouridine
0 ImagesCat. No.: HY-1543702’,3’-Bis-O-(t-butyldimethylsilyl)-N1-methylpseudouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine
0 ImagesCat. No.: HY-154547CAS No.: 256224-04-1N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
0 ImagesCat. No.: HY-152436CAS No.: 2389988-23-07-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
