PARP
poly ADP ribose polymerase
PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair.
PARP Isoform Specific Products
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PARP
(302)
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PARP1
(200)
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PARP2
(82)
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PARP3
(22)
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PARP4
(11)
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TNKS1/PARP5A
(40)
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TNKS2/PARP5B
(37)
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PARP7
(24)
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PARP10
(20)
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PARP14
(17)
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PARP15
(14)
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PARP12
(4)
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PARP16
(3)
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All Product Categories
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PARP Inhibitors
(455)
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PARP Agonists
(4)
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PARP Activators
(99)
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PARP Modulators
(10)
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PARP Inducers
(20)
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PARP Degraders
(23)
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PARP Substrate
(1)
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PARP Ligands
(4)
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PARP Related Products (674)
Related Products (674)
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Antibodies (11)
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PARP Isoform Comparison
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Nesuparib hydrochloride
0 ImagesCat. No.: HY-145584ACAS No.: 2055357-65-6Synonyms: JPI-547/OCN-201 hydrochloride
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Rucaparib hydrochloride
0 ImagesCat. No.: HY-10617BCAS No.: 773059-19-1Synonyms: AG014699 hydrochloride; PF-01367338 hydrochlorideRucaparib (AG014699) hydrochloride is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib hydrochloride is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib hydrochloride has the potential for castration-resistant prostate cancer (CRPC) research.
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Nudifloramide-d6
0 ImagesCat. No.: HY-113432S1CAS No.: 2012598-72-8Synonyms: 2PY-d6
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Anticancer agent 71
0 ImagesCat. No.: HY-147906CAS No.: 2453228-45-8Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.
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2-Methylquinazolin-4-ol (Standard)
0 Images2-Methylquinazolin-4-ol (Standard) is the analytical standard of 2-Methylquinazolin-4-ol. This product is intended for research and analytical applications. 2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].
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PARP/VEGFR3-IN-1
0 ImagesCat. No.: HY-179020PARP/VEGFR3-IN-1 (Compound 18) is a dual PARP-VEGFR3 target inhibitor. Its IC50 values for PARP1, PARP2, and VEGFR3 are 0.0763, 0.0366, and 4.25 nM respectively. PARP/VEGFR3-IN-1 has no inhibitory effect on VEGFR1/2 and shows subtype selectivity. PARP/VEGFR3-IN-1 exhibits significant anti-proliferative activity in various cancer cells (leukemia, lung cancer, and triple-negative breast cancer). PARP/VEGFR3-IN-1 induces DNA damage and cell cycle arrest. PARP/VEGFR3-IN-1 triggers various forms of cell death by inducing apoptosis and autophagy. PARP/VEGFR3-IN-1 can be formulated into nanodelivery systems, significantly enhancing tumor targeting and therapeutic window.
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2H-Indazole-7-carboxamide
0 ImagesCat. No.: HY-W973851CAS No.: 952479-70-8
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AKT-IN-28
0 ImagesCat. No.: HY-174254CAS No.: 3099809-16-9AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells.
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Trijuganone C
0 ImagesCat. No.: HY-N8617CAS No.: 135247-94-8Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells.
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Echinoside A
0 ImagesCat. No.: HY-N17442CAS No.: 75410-53-6Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species.
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LD5097
0 ImagesCat. No.: HY-179234LD5097 is a highly effective and selective PROTAC degrader targeting RIPK1. LD5097 can rapidly and efficiently downregulate RIPK1 and significantly enhance TNFα-mediated apoptosis in Jurkat cells. LD5097 significantly increases the levels of cleaved caspase-3/7 and PARP. LD5097 can be used for the study of acute T-lymphoblastic leukemia.
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PARP7-IN-19
0 ImagesCat. No.: HY-163492CAS No.: 3033778-34-3PARP7-IN-19 (compound 5a) is an inhibitor of PARP7 ( IC50 ≤10nM). PARP7-IN-19 can be used in the research area of tumors.
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Lerzeparib
0 ImagesCat. No.: HY-156623CAS No.: 2459693-01-5Lerzeparib is an (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity.
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EAPB0503
0 ImagesCat. No.: HY-171184CAS No.: 1140627-77-5EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein .
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Topoisomerase I/II inhibitor 8
0 ImagesCat. No.: HY-169509CAS No.: 355400-87-2Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment.
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PARP1-IN-9
0 ImagesCat. No.: HY-149001CAS No.: 2494000-71-2PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) .
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PARP-2-IN-3
0 ImagesCat. No.: HY-151625CAS No.: 2915650-86-9
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AC-45594
0 ImagesSynonyms: 4-(Hexyloxy)phenolAC-45594 (4-(Hexyloxy)phenol) is a UPR activator. AC-45594 induces endoplasmic reticulum stress, activates the unfolded protein response (UPR), and drives the transition from adaptive stress signaling to terminal stress signaling, ultimately leading to cell Apoptosis. AC-45594 activates Caspase-3, induces PARP cleavage, and increases the protein level of DR5. AC-45594 selectively inhibits the growth of Ewing sarcoma cells.
