PIKfyve
FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase; Fab1
PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene. The principal enzymatic activity of PIKfyve is to phosphorylate PtdIns3P to PtdIns(3,5)P2. PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P). PIKfyve is a large protein, containing a number of functional domains and expressed in several spliced forms. By directly binding membrane PtdIns(3)P, the FYVE finger domain of PIKfyve is essential in localizing the protein to the cytosolic leaflet of endosomes. Impaired PIKfyve enzymatic activity by dominant-interfering mutants, siRNA- mediated ablation or pharmacological inhibition causes endosome enlargement and cytoplasmic vacuolation due to impaired PtdIns(3,5)P2 synthesis. Thus, via PtdIns(3,5)P2 production, PIKfyve participates in several aspects of endosome dynamics, thereby affecting a number of trafficking pathways that emanate from or traverse the endosomal system en route to the trans-Golgi network or later compartments along the endocytic pathway.
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PIKfyve Related Products (22)
Related Products (22)
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Antibodies (1)
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Apilimod (Standard)
0 ImagesCat. No.: HY-14644RCAS No.: 541550-19-0Apilimod (Standard) is the analytical standard of Apilimod (HY-14644). This product is intended for research and analytical applications. Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. Apilimod is a potent and highly selective PIKfyve inhibitor.
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PIKfyve-IN-5
0 ImagesCat. No.: HY-189387PIKfyve-IN-5 is a PIKfyve inhibitor (IC50 = 32 nM) with selective antiviral activity. PIKfyve-IN-5 inhibits PIKfyve and blocks the release of the viral genome from endosomes into the cytosol by sequestering viral particles within swollen spherical vacuoles. PIKfyve-IN-5 exhibits antiviral activity against SARS-CoV-2 in human lung epithelial cells. PIKfyve-IN-5 can be used for research on SARS-CoV-2 infection.
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