2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PIKfyve
  5. PIKfyve Degrader

PIKfyve Degrader

PIKfyve Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-175631
    PIKfyve ligand-1
    		Degrader
    PIKfyve ligand-1 is a PIKfyve ligand, which can be used for the synthesis of PROTACs, such as PIK5-12d (HY-155994).
  • HY-155994
    PIK5-12d
    		Degrader 99.15%
    PIK5-12d is a PROTAC PIKfyve degrader (DC50 = 1.48 nM). PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d significantly suppresses tumor proliferation in mice bearing LTL-331R human prostate cancer PDX tumors. PIK5-12d can be used for the study of prostate cancer.
  • HY-153119
    TMX-4153
    		Degrader 98.96%
    TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker).