2867519-91-1

TMX-4153 Chemical Structure
2867519-91-1

Chemical Structure

TMX-4153

  • CAS No.: 2867519-91-1
  • Formula:C59H67ClN10O6S
  • Molecular Weight:1079.74

IUPAC Name: (2S,4R)-1-((S)-2-(7-(2-(5-((4-([1,1'-biphenyl]-3-yl)-5-chloropyrimidin-2-yl)amino)pyridin-3-yl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

InChIKey: NIQFZCJNEODJTE-CSIWTOAPSA-N

SMILES: ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4

Biological Activity: TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker)[1].

Cat. No. Product Name Purity Description Pricing
HY-153119 		TMX-4153 98.96% TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker).
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This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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