2867519-91-1
Chemical Structure
TMX-4153
- CAS No.: 2867519-91-1
- Formula:C59H67ClN10O6S
- Molecular Weight:1079.74
IUPAC Name: (2S,4R)-1-((S)-2-(7-(2-(5-((4-([1,1'-biphenyl]-3-yl)-5-chloropyrimidin-2-yl)amino)pyridin-3-yl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: NIQFZCJNEODJTE-CSIWTOAPSA-N
SMILES: ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4
Biological Activity: TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TMX-4153 | 98.96% | TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker). | ||||||||||||||||||||
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Keywords
