PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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BnO-PEG5-OH
0 ImagesCat. No.: HY-W042714CAS No.: 57671-28-0
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Fmoc-N-amido-PEG2-alcohol
0 ImagesCat. No.: HY-W096094CAS No.: 299430-87-8
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Biotin-PEG4-TFP ester
0 ImagesCat. No.: HY-140903CAS No.: 2985664-57-9
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11-Bromoundecanoic acid
0 ImagesCat. No.: HY-W009413CAS No.: 2834-05-111-Bromoundecanoic acid is a PROTAC linker that can be used for the synthesis of PROTACs, such as INY-05-040 (HY-160469).
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Bis-Mal-PEG3
0 ImagesCat. No.: HY-140993CAS No.: 1008402-47-8
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Biotin-PEG11-azide
0 ImagesBiotin-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG8-CH2COOH
0 ImagesCat. No.: HY-130145CAS No.: 102013-72-9
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HO-PEG13-OH
0 ImagesCat. No.: HY-141234CAS No.: 17598-96-8
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Tos-O-C4-NH-Boc
0 ImagesCat. No.: HY-132004CAS No.: 180851-50-7Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250).
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1-(1,1-Dimethylethyl) tridecanedioate
0 ImagesCat. No.: HY-W881439CAS No.: 2703752-86-51-(1,1-Dimethylethyl) tridecanedioate is a PROTAC Linker and can be used for PROTAC synthesis, such as FF2039 (HY-172159).
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N-Boc-4-hydroxy-L-proline methyl ester
0 ImagesN-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
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DBCO-PEG2-acid
0 ImagesCat. No.: HY-140266CAS No.: 2304558-25-4
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Propargyl-PEG6-acid
0 ImagesCat. No.: HY-130386CAS No.: 1951438-84-8Propargyl-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG6-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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trans-4-Cyanocyclohexane-1-carboxylic acid
0 ImagesCat. No.: HY-W090286CAS No.: 15177-68-1
