PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Produits associés (4102)
Produits associés (4102)
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PROTAC Linkers Isoform Comparison
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Dde Biotin-PEG4-azide
0 ImagesDde Biotin-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Dde Biotin-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl N-[2-(aminooxy)ethyl]carbamate
![tert-Butyl N-[2-(aminooxy)ethyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w056118.gif "Click to View tert-Butyl N-[2-(aminooxy)ethyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W056118CAS No.: 75051-55-7
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tert-Butyl N-methyl-N-(piperidin-4-ylmethyl)carbamate
0 ImagesCat. No.: HY-59252CAS No.: 138022-04-5
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Potassium (2-benzyloxyethyl)trifluoroborate
0 ImagesCat. No.: HY-W155163CAS No.: 1408168-73-9
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1-(2-Aminoethyl)piperidin-4-ol
0 ImagesCat. No.: HY-W046450CAS No.: 129999-60-6
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tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate
![tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w050185.gif "Click to View tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W050185CAS No.: 1638763-38-8
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CbzNH-PEG3-OH
0 ImagesCat. No.: HY-W190967CAS No.: 205535-92-8
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Benzyl 3-(hydroxymethyl)azetidine-1-carboxylate
0 ImagesCat. No.: HY-W058000CAS No.: 618446-42-7
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tert-Butyl (4-hydroxycyclohexyl)carbamate
0 ImagesCat. No.: HY-W042233CAS No.: 224309-64-2
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tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-20669CAS No.: 219725-67-4
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tert-Butyl 4-(3-aminopropyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W043300CAS No.: 150349-65-8
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Tert-butyl 4-(3-chloropropyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W176791CAS No.: 165530-45-0
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Thiol-PEG8-alcohol
0 ImagesSynonyms: HS-PEG8-OH
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1,6-Diiodohexane
0 ImagesCat. No.: HY-W011198CAS No.: 629-09-4
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3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)propanoic acid
0 ImagesCat. No.: HY-W349243CAS No.: 882847-07-6
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Fmoc-NH-PEG4-alcohol
0 ImagesCat. No.: HY-133470CAS No.: 868594-41-6
![4-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid](https://file.medchemexpress.com/product_pic/hy-34261.gif "Click to View 4-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid Product Detail")
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{3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol
![{3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol](https://file.medchemexpress.com/product_pic/hy-w061103.gif "Click to View {3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol Product Detail")
0 ImagesCat. No.: HY-W061103CAS No.: 1394119-83-5
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Cbz-NH-PEG12-C2-acid
0 ImagesCat. No.: HY-133358CAS No.: 1334177-88-6
