PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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4-Bromophenylacetonitrile
0 ImagesCat. No.: HY-Y0146CAS No.: 16532-79-9
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tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-77169CAS No.: 135716-09-5
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Heptadecanedioic acid
0 ImagesCat. No.: HY-W034594CAS No.: 2424-90-0
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9-Aminononan-1-ol
0 ImagesCat. No.: HY-W250761CAS No.: 109055-42-7Synonyms: 9-Amino-1-nonanol
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Cyclohexane-1,4-diyldimethanamine
0 ImagesCat. No.: HY-W087970CAS No.: 2549-93-1
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4-(2-Bromoethyl)benzonitrile
0 ImagesCat. No.: HY-W017920CAS No.: 72054-56-9
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4-Methoxycarbonylcubanecarboxylic acid
0 ImagesCat. No.: HY-W058129CAS No.: 24539-28-4
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Tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate
0 ImagesCat. No.: HY-W116795CAS No.: 134892-19-6
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Benzyl (3-aminopropyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W012016CAS No.: 17400-34-9
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3,3'-Oxybis(propan-1-ol)
0 ImagesCat. No.: HY-W077191CAS No.: 2396-61-4Synonyms: 3,3'-Oxydipropanol
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rel-(1S,2R)-2-(((tert-butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylic acid
0 ImagesCat. No.: HY-W364968CAS No.: 1638768-80-5
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Methyl 7-bromoheptanoate
0 ImagesCat. No.: HY-W004688CAS No.: 54049-24-0
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(9H-Fluoren-9-yl)methyl (5-hydroxypentyl)carbamate
0 ImagesCat. No.: HY-W072176CAS No.: 209115-33-3
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cis-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
0 ImagesCat. No.: HY-W057903CAS No.: 1628475-90-0
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Pent-4-ynal
0 ImagesCat. No.: HY-W612158CAS No.: 18498-59-4
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3-Aminobicyclo[1.1.1]pentane-1-carbonitrile
![3-Aminobicyclo[1.1.1]pentane-1-carbonitrile](https://file.medchemexpress.com/product_pic/hy-w059686.gif "Click to View 3-Aminobicyclo[1.1.1]pentane-1-carbonitrile Product Detail")
0 ImagesCat. No.: HY-W059686CAS No.: 1936643-30-9
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5-((tert-Butyldimethylsilyl)oxy)pentanoic acid
0 ImagesCat. No.: HY-W247308CAS No.: 87729-39-3
