PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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tert-Butyl 17-bromoheptadecanoate
0 ImagesCat. No.: HY-W251705CAS No.: 2428400-70-6
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tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
![tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w056130.gif "Click to View tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W056130CAS No.: 871022-62-7
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2-(Prop-2-yn-1-yloxy)acetic acid
0 ImagesCat. No.: HY-W026075CAS No.: 98021-61-5
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3-Benzyl-3,9-diazaspiro[5.5]undecane
![3-Benzyl-3,9-diazaspiro[5.5]undecane](https://file.medchemexpress.com/product_pic/hy-30534.gif "Click to View 3-Benzyl-3,9-diazaspiro[5.5]undecane Product Detail")
0 ImagesCat. No.: HY-30534CAS No.: 189333-49-1
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4-(2-((tert-Butoxycarbonyl)amino)ethyl)benzoic acid
0 ImagesCat. No.: HY-60350CAS No.: 132690-91-6
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2-(4-Ethynylphenyl)acetonitrile
0 ImagesCat. No.: HY-W015722CAS No.: 351002-90-9
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Fmoc-Gly-NH-CH2-O-CH2-Cbz
0 ImagesCat. No.: HY-46346CAS No.: 1599440-07-9Fmoc-Gly-NH-CH2-O-CH2-Cbz is a PROTAC linker and a maleimide-GGFG peptide linker. Fmoc-Gly-NH-CH2-O-CH2-Cbz can be used in the synthesis of the Deruxtecan.
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Thiol-PEG6-alcohol
0 ImagesCat. No.: HY-130580CAS No.: 194425-46-2Synonyms: HS-PEG6-OH
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1-Boc-4-(Aminomethyl)piperidine hydrochloride
0 ImagesCat. No.: HY-W018866CAS No.: 359629-16-6
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tert-Butyl 2-(4-aminophenyl)acetate
0 ImagesCat. No.: HY-W050294CAS No.: 174579-31-8
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NHBoc-PEG3-I
0 ImagesCat. No.: HY-W577841CAS No.: 1801273-41-5
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7-Methoxy-7-oxoheptanoic acid
0 ImagesCat. No.: HY-W001494CAS No.: 20291-40-1
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Boc-12-Ado-OH
0 ImagesCat. No.: HY-W101723CAS No.: 18934-81-1Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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2-(2-Iodoethoxy)ethan-1-ol
0 ImagesCat. No.: HY-W092944CAS No.: 130536-69-5
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cis-5-Amino-2-Boc-hexahydro-cyclopenta[c]pyrrole
![cis-5-Amino-2-Boc-hexahydro-cyclopenta[c]pyrrole](https://file.medchemexpress.com/product_pic/hy-w057815.gif "Click to View cis-5-Amino-2-Boc-hexahydro-cyclopenta[c]pyrrole Product Detail")
0 ImagesCat. No.: HY-W057815CAS No.: 863600-81-1
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rel-((1S,2R)-2-(Methoxycarbonyl)cyclopropane-1-carboxylic acid)
0 ImagesCat. No.: HY-W061724CAS No.: 31420-47-0
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4-(Benzyloxy)-4-oxobutanoic acid
0 ImagesCat. No.: HY-W002611CAS No.: 103-40-2
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4-Ethoxycarbonylmethylphenylboronic acid pinacol ester
0 ImagesCat. No.: HY-77699CAS No.: 859169-20-3
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6-Aminohexanenitrile
0 ImagesCat. No.: HY-W095448CAS No.: 2432-74-8
