PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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2-[3-(Methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]acetic acid
![2-[3-(Methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]acetic acid](https://file.medchemexpress.com/product_pic/hy-w063710.gif "Click to View 2-[3-(Methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]acetic acid Product Detail")
0 ImagesCat. No.: HY-W063710CAS No.: 1113001-63-0
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tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W008279ACAS No.: 165391-09-3
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tert-Butyl cis-4-(hydroxymethyl)cyclohexylcarbamate
0 ImagesCat. No.: HY-W063916CAS No.: 223131-01-9
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tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate
![tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056566.gif "Click to View tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056566CAS No.: 203662-55-9
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tert-Butyl 4-(methylamino)butanoate hydrochloride
0 ImagesCat. No.: HY-W442050CAS No.: 1246527-48-9
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tert-Butyl (4-aminobutyl)(methyl)carbamate
0 ImagesCat. No.: HY-40179CAS No.: 144222-23-1
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13-Bromotridecan-1-ol
0 ImagesCat. No.: HY-W033979CAS No.: 116754-58-6
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Monomethyl adipate
0 ImagesCat. No.: HY-W017222CAS No.: 627-91-8
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2-(Aminooxy)ethanamine dihydrochloride
0 ImagesCat. No.: HY-78768CAS No.: 37866-45-8
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3,3'-Thiodipropanoic acid
0 ImagesCat. No.: HY-W016614CAS No.: 111-17-1
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Undecane-1,11-diol
0 ImagesSynonyms: 1,11-Undecanediol
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9-Decyn-1-ol
0 ImagesCat. No.: HY-130985CAS No.: 17643-36-69-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. 9-Decyn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Fmoc-NH-PEG9-CH2CH2COOH
0 ImagesFmoc-NH-PEG9-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG9-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Amino-PEG16-acid
0 ImagesCat. No.: HY-140179CAS No.: 2922656-52-6
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Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane
0 ImagesAzido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
