PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Produits associés (4102)
Produits associés (4102)
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PROTAC Linkers Isoform Comparison
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S-acetyl-PEG4-propargyl
0 ImagesCat. No.: HY-141350CAS No.: 1422540-88-2
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Bromo-PEG6-Boc
0 ImagesCat. No.: HY-141367CAS No.: 1393330-41-0
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Carboxy-PEG4-phosphonic acid
0 ImagesCat. No.: HY-141302CAS No.: 1623791-69-4
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3,9-Dimethyl-3,9-diazaspiro[5.5]undecane
![3,9-Dimethyl-3,9-diazaspiro[5.5]undecane](https://file.medchemexpress.com/product_pic/hy-46871.gif "Click to View 3,9-Dimethyl-3,9-diazaspiro[5.5]undecane Product Detail")
0 ImagesCat. No.: HY-46871CAS No.: 93004-48-9
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NH-bis-PEG2
0 ImagesCat. No.: HY-130328CAS No.: 54384-47-3NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Amino-PEG12-amine
0 ImagesSynonyms: H2N-PEG12-CH2CH2NH2
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Boc-NH-PEG2-NH-Boc
0 ImagesCat. No.: HY-141198CAS No.: 475591-59-4
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tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate
![tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w088456.gif "Click to View tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W088456CAS No.: 874831-60-4
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Propargyl-PEG6-alcohol
0 ImagesCat. No.: HY-130382CAS No.: 944560-99-0
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Azido-PEG10-acid
0 ImagesAzido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3,4-Dibromo-Mal-PEG2-N-Boc
0 ImagesCat. No.: HY-141005CAS No.: 1807537-43-4
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S-acetyl-PEG4-amine TFA
0 ImagesCat. No.: HY-138752APureté: 98.0%
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Ethyl azetidine-3-carboxylate hydrochloride
0 ImagesEthyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]-
m-PEG6-O-CH2COOH
0 ImagesCat. No.: HY-140506CAS No.: 75427-75-7
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Benzyl-PEG4-amine
0 ImagesCat. No.: HY-W096073CAS No.: 86770-76-5
