2. PROTAC
  3. PROTAC Linkers
  4. NH-bis(C1-PEG1-Boc)

NH-bis(C1-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH-bis(C1-PEG1-Boc) Chemical Structure

NH-bis(C1-PEG1-Boc) Chemical Structure

CAS No. : 2171072-53-8

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Based on 1 publication(s) in Google Scholar

NH-bis(C1-PEG1-Boc) Related Antibodies

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Description

NH-bis(C1-PEG1-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH-bis(C1-PEG1-Boc) Related Antibodies
Molecular Weight

347.45

Formula

C17H33NO6
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

NC(COCCC(OC(C)(C)C)=O)COCCC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (287.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8781 mL 14.3906 mL 28.7811 mL
5 mM 0.5756 mL 2.8781 mL 5.7562 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8781 mL 14.3906 mL 28.7811 mL 71.9528 mL
5 mM 0.5756 mL 2.8781 mL 5.7562 mL 14.3906 mL
10 mM 0.2878 mL 1.4391 mL 2.8781 mL 7.1953 mL
15 mM 0.1919 mL 0.9594 mL 1.9187 mL 4.7969 mL
20 mM 0.1439 mL 0.7195 mL 1.4391 mL 3.5976 mL
25 mM 0.1151 mL 0.5756 mL 1.1512 mL 2.8781 mL
30 mM 0.0959 mL 0.4797 mL 0.9594 mL 2.3984 mL
40 mM 0.0720 mL 0.3598 mL 0.7195 mL 1.7988 mL
50 mM 0.0576 mL 0.2878 mL 0.5756 mL 1.4391 mL
60 mM 0.0480 mL 0.2398 mL 0.4797 mL 1.1992 mL
80 mM 0.0360 mL 0.1799 mL 0.3598 mL 0.8994 mL
100 mM 0.0288 mL 0.1439 mL 0.2878 mL 0.7195 mL
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NH-bis(C1-PEG1-Boc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH-bis(C1-PEG1-Boc)2171072-53-8PROTAC LinkersInhibitorinhibitorinhibit

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