Aminooxy-PEG3-propargyl
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Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1807537-27-4
- Formula: C9H17NO4
- Molecular Weight:203.24
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1807537-27-4
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Appearance Liquid (Density: 1.069±0.06 g/cm3)
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Molecular Weight 203.24
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Formula C9H17NO4
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Color Colorless to light yellow
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SMILES
NOCCOCCOCCOCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 250 mg/mL (1230.07 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9203 mL | 24.6015 mL | 49.2029 mL | 123.0073 mL |
| 5 mM | 0.9841 mL | 4.9203 mL | 9.8406 mL | 24.6015 mL | |
| 10 mM | 0.4920 mL | 2.4601 mL | 4.9203 mL | 12.3007 mL | |
| 15 mM | 0.3280 mL | 1.6401 mL | 3.2802 mL | 8.2005 mL | |
| 20 mM | 0.2460 mL | 1.2301 mL | 2.4601 mL | 6.1504 mL | |
| 25 mM | 0.1968 mL | 0.9841 mL | 1.9681 mL | 4.9203 mL | |
| 30 mM | 0.1640 mL | 0.8200 mL | 1.6401 mL | 4.1002 mL | |
| 40 mM | 0.1230 mL | 0.6150 mL | 1.2301 mL | 3.0752 mL | |
| 50 mM | 0.0984 mL | 0.4920 mL | 0.9841 mL | 2.4601 mL | |
| 60 mM | 0.0820 mL | 0.4100 mL | 0.8200 mL | 2.0501 mL | |
| 80 mM | 0.0615 mL | 0.3075 mL | 0.6150 mL | 1.5376 mL | |
| 100 mM | 0.0492 mL | 0.2460 mL | 0.4920 mL | 1.2301 mL |
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