PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Cbz-PEG2-prop-1-yne
0 ImagesCat. No.: HY-W583812CAS No.: 2680770-53-8
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Methyl 5-bromo-4-oxopentanoate
0 ImagesCat. No.: HY-W022935CAS No.: 53856-93-2
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Methyl 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylate
0 ImagesCat. No.: HY-W047436CAS No.: 914347-01-6
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6-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid
0 ImagesCat. No.: HY-W107032CAS No.: 173690-47-6
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tert-Butyl N-[3-(hydroxymethyl)cyclobutyl]carbamate
![tert-Butyl N-[3-(hydroxymethyl)cyclobutyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w056109.gif "Click to View tert-Butyl N-[3-(hydroxymethyl)cyclobutyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W056109CAS No.: 130369-05-0
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20-Bromoicosanoic acid
0 ImagesCat. No.: HY-W614895CAS No.: 876476-87-8
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Methyl 2-(chlorosulfonyl)acetate
0 ImagesCat. No.: HY-W612003CAS No.: 56146-83-9
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2-(1-benzylpiperidin-4-yl)ethan-1-amine
0 ImagesCat. No.: HY-W140988CAS No.: 86945-25-7
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tert-Butyl 6-iodohexanoate
0 ImagesCat. No.: HY-W460254CAS No.: 67899-04-1
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trans-4-Aminocyclohexanol hydrochloride
0 ImagesCat. No.: HY-W042291CAS No.: 50910-54-8
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2-tert-Butyl 6-methyl 2-azaspiro[3.3]heptane-2,6-dicarboxylate
![2-tert-Butyl 6-methyl 2-azaspiro[3.3]heptane-2,6-dicarboxylate](https://file.medchemexpress.com/product_pic/hy-w059942.gif "Click to View 2-tert-Butyl 6-methyl 2-azaspiro[3.3]heptane-2,6-dicarboxylate Product Detail")
0 ImagesCat. No.: HY-W059942CAS No.: 1408074-81-6
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Boc-pyrrolidine-cyclopentanamine
0 ImagesCat. No.: HY-W056291CAS No.: 1341037-08-8
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N-(3-Hydroxypropyl)carbamic acid benzyl ester
0 ImagesCat. No.: HY-W039951CAS No.: 34637-22-4
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tert-Butyl 4-(4-cyanophenyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W039512CAS No.: 186650-98-6
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3-Benzyloxy-propionic acid methyl ester
0 ImagesCat. No.: HY-W295865CAS No.: 4126-60-7
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3-tert-Butyl-4-methoxyphenol
0 Images3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system.
![Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w006763.gif "Click to View Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate hydrochloride Product Detail")
