PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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tert-Butyl 7-iodoheptanoate
0 ImagesCat. No.: HY-W460233CAS No.: 54005-76-4
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((2-Iodoethoxy)methyl)benzene
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1-Cbz-Azetidine-3-CH2NH2
0 ImagesCat. No.: HY-W058001CAS No.: 1016731-24-0
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Mal-amido-PEG9-acid
0 ImagesSynonyms: Maleimide-NH-PEG9-CH2CH2COOH
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Methyl 9-bromononanoate
0 ImagesCat. No.: HY-W088462CAS No.: 67878-15-3
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2-(3-((Tert-butoxycarbonyl)amino)cyclobutyl)acetic acid
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N-Boc-N-methyl-3-chloro-1-propanamine
0 ImagesCat. No.: HY-W102175CAS No.: 114326-14-6
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1,4-Cyclohexanedimethanol
0 ImagesCat. No.: HY-W015663CAS No.: 105-08-8
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Carbobenzoxy-4-aminobutyric acid
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tert-Butyl (10-bromodecyl)carbamate
0 ImagesCat. No.: HY-W077352CAS No.: 887353-29-9
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3-(Piperazin-1-yl)propan-1-ol
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12-(Benzyloxy)-12-oxododecanoic acid
0 ImagesCat. No.: HY-W129669CAS No.: 88353-04-2
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6-Bromohexanenitrile
0 ImagesCat. No.: HY-W105754CAS No.: 6621-59-6
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Methyl 8-bromooctanoate
0 ImagesCat. No.: HY-W088478CAS No.: 26825-92-3
![Methyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate](https://file.medchemexpress.com/product_pic/hy-35451.gif "Click to View Methyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate Product Detail")
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Benzyl (4-hydroxybutyl)carbamate
0 ImagesCat. No.: HY-W038309CAS No.: 17996-13-3
