Mal-amido-PEG9-acid (Synonyms: Maleimide-NH-PEG9-CH2CH2COOH)

Cat. No.: HY-130856 Purity: 99.07%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-amido-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-amido-PEG9-acid Chemical Structure

CAS No. : 2112731-43-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
50 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Mal-amido-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

636.69

Formula

C₂₈H₄₈N₂O₁₄

CAS No.

2112731-43-6

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=CC(N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (157.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5706 mL	7.8531 mL	15.7062 mL
5 mM	0.3141 mL	1.5706 mL	3.1412 mL
10 mM	0.1571 mL	0.7853 mL	1.5706 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.07%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (256 KB) HNMR (274 KB) LCMS (257 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5706 mL	7.8531 mL	15.7062 mL	39.2656 mL
	5 mM	0.3141 mL	1.5706 mL	3.1412 mL	7.8531 mL
	10 mM	0.1571 mL	0.7853 mL	1.5706 mL	3.9266 mL
	15 mM	0.1047 mL	0.5235 mL	1.0471 mL	2.6177 mL
	20 mM	0.0785 mL	0.3927 mL	0.7853 mL	1.9633 mL
	25 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5706 mL
	30 mM	0.0524 mL	0.2618 mL	0.5235 mL	1.3089 mL
	40 mM	0.0393 mL	0.1963 mL	0.3927 mL	0.9816 mL
	50 mM	0.0314 mL	0.1571 mL	0.3141 mL	0.7853 mL
	60 mM	0.0262 mL	0.1309 mL	0.2618 mL	0.6544 mL
	80 mM	0.0196 mL	0.0982 mL	0.1963 mL	0.4908 mL
	100 mM	0.0157 mL	0.0785 mL	0.1571 mL	0.3927 mL

Mal-amido-PEG9-acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-amido-PEG9-acid2112731-43-6Maleimide-NH-PEG9-CH2CH2COOHPROTAC LinkersInhibitorinhibitorinhibit

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