PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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2,2-Oxybis(ethylamine) dihydrochloride
0 ImagesCat. No.: HY-W006284CAS No.: 60792-79-2
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Cyano-C2-PEG3-cyano
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2-(4-(Methoxycarbonyl)phenoxy)acetic acid
0 ImagesCat. No.: HY-W044833CAS No.: 90812-66-1
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tert-Butyl 2-(piperidin-4-yl)acetate oxalate
0 ImagesCat. No.: HY-W042245CAS No.: 1360438-13-6
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tert-Butyl ((trans-4-aminocyclohexyl)methyl)carbamate
0 ImagesCat. No.: HY-W055910CAS No.: 192323-07-2
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8-((tert-Butoxycarbonyl)amino)octyl 4-methylbenzenesulfonate
0 ImagesCat. No.: HY-W109273CAS No.: 1472656-81-7
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Methyl 3-aminocyclobutane-1-carboxylate hydrochloride
0 ImagesCat. No.: HY-W003888CAS No.: 1354940-69-4
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tert-Butyl methyl(3-oxopropyl)carbamate
0 ImagesCat. No.: HY-W141219CAS No.: 273757-11-2
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tert-Butyl (3-(piperidin-4-yl)propyl)carbamate
0 ImagesCat. No.: HY-W583818CAS No.: 885268-87-1
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Methyl 10-bromodecanoate
0 ImagesCat. No.: HY-W088477CAS No.: 26825-94-5
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Sebaconitrile
0 ImagesCat. No.: HY-W130919CAS No.: 1871-96-1
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tert-Butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)carbamate
0 ImagesCat. No.: HY-W095444CAS No.: 360792-43-4
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OH-PEG2-C3-NH2
0 ImagesCat. No.: HY-W112031CAS No.: 112-33-4
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tert-Butyl (1-(2-aminoethyl)piperidin-4-yl)carbamate
0 ImagesCat. No.: HY-W087437CAS No.: 259180-79-5
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(9H-Fluoren-9-yl)methyl (6-hydroxyhexyl)carbamate
0 ImagesCat. No.: HY-W097011CAS No.: 127903-20-2
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5-Chloropentanenitrile
0 ImagesCat. No.: HY-W041621CAS No.: 6280-87-1Synonyms: Chlorovaleronitrile
