Cbz-NH-PEG1-CH2COOH
Based on 1 Customer Validation
Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 1260092-43-0
- Formula: C12H15NO5
- Molecular Weight:253.25
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1260092-43-0
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Appearance Solid
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Molecular Weight 253.25
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Formula C12H15NO5
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Color White to off-white
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SMILES
O=C(O)COCCNC(OCC1=CC=CC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (394.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9487 mL | 19.7433 mL | 39.4867 mL | 98.7167 mL |
| 5 mM | 0.7897 mL | 3.9487 mL | 7.8973 mL | 19.7433 mL | |
| 10 mM | 0.3949 mL | 1.9743 mL | 3.9487 mL | 9.8717 mL | |
| 15 mM | 0.2632 mL | 1.3162 mL | 2.6324 mL | 6.5811 mL | |
| 20 mM | 0.1974 mL | 0.9872 mL | 1.9743 mL | 4.9358 mL | |
| 25 mM | 0.1579 mL | 0.7897 mL | 1.5795 mL | 3.9487 mL | |
| 30 mM | 0.1316 mL | 0.6581 mL | 1.3162 mL | 3.2906 mL | |
| 40 mM | 0.0987 mL | 0.4936 mL | 0.9872 mL | 2.4679 mL | |
| 50 mM | 0.0790 mL | 0.3949 mL | 0.7897 mL | 1.9743 mL | |
| 60 mM | 0.0658 mL | 0.3291 mL | 0.6581 mL | 1.6453 mL | |
| 80 mM | 0.0494 mL | 0.2468 mL | 0.4936 mL | 1.2340 mL | |
| 100 mM | 0.0395 mL | 0.1974 mL | 0.3949 mL | 0.9872 mL |
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