PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Desthiobiotin-PEG3-sulfo-Maleimide
0 ImagesCat. No.: HY-163790CAS No.: 3121260-22-5Desthiobiotin-PEG3-sulfo-Maleimide is a PEG linker can be used in the synthesis of PROTACs.
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Azido-PEG8-THP
0 ImagesCat. No.: HY-132055Azido-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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NH2-PEG5-C6-Cl
0 ImagesCat. No.: HY-129622CAS No.: 1261238-22-5NH2-PEG5-C6-Cl (K-7) is a linker which refers to the PEG composition. NH2-PEG5-C6-Cl can be used in the synthesis of a series of compounds that induce degradation of intracellular molecules by autophagy.
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TCO-PEG24-NHS ester
0 ImagesCat. No.: HY-141171CAS No.: 2055646-26-7
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Amino-PEG27-amine
0 ImagesCat. No.: HY-133330CAS No.: 2252208-09-4Synonyms: H2N-PEG27-CH2CH2NH2
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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
0 ImagesCat. No.: HY-140095CAS No.: 2112732-01-9N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5
0 ImagesCat. No.: HY-141071CAS No.: 2107273-76-5
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Decanedioic acid-13C2
0 ImagesCat. No.: HY-W014787S2Synonyms: Sebacic acid-13C2Decanedioic acid-13C2 (Sebacic acid-13C2) is the 13C-labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
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Aminooxy-PEG4-C2-Boc
0 ImagesCat. No.: HY-140402CAS No.: 2100306-82-7
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Propargyl-PEG2-N-bis(PEG2)
0 ImagesCat. No.: HY-140083CAS No.: 2100306-62-3
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Benzyl-PEG5-NHBoc
0 ImagesCat. No.: HY-138378CAS No.: 2064292-55-1
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Biotin-PEG5000-Alk
0 ImagesCat. No.: HY-147206D
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Benzyl-PEG3-CH2-Boc
0 ImagesCat. No.: HY-130738CAS No.: 1443467-88-6
