1. PROTAC
  2. PROTAC Linkers
  3. Benzyl-PEG2-CH2-Boc

Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Benzyl-PEG2-CH2-Boc Chemical Structure

Benzyl-PEG2-CH2-Boc Chemical Structure

CAS No. : 1643957-26-9

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50 mg USD 80 In-stock
100 mg USD 120 In-stock
250 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

310.39

Formula

C17H26O5

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)COCCOCCOCC1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (161.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2218 mL 16.1088 mL 32.2175 mL
5 mM 0.6444 mL 3.2218 mL 6.4435 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2218 mL 16.1088 mL 32.2175 mL 80.5438 mL
5 mM 0.6444 mL 3.2218 mL 6.4435 mL 16.1088 mL
10 mM 0.3222 mL 1.6109 mL 3.2218 mL 8.0544 mL
15 mM 0.2148 mL 1.0739 mL 2.1478 mL 5.3696 mL
20 mM 0.1611 mL 0.8054 mL 1.6109 mL 4.0272 mL
25 mM 0.1289 mL 0.6444 mL 1.2887 mL 3.2218 mL
30 mM 0.1074 mL 0.5370 mL 1.0739 mL 2.6848 mL
40 mM 0.0805 mL 0.4027 mL 0.8054 mL 2.0136 mL
50 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.6109 mL
60 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3424 mL
80 mM 0.0403 mL 0.2014 mL 0.4027 mL 1.0068 mL
100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.8054 mL
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Benzyl-PEG2-CH2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Benzyl-PEG2-CH2-Boc
Cat. No.:
HY-130172
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