PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Azido-PEG20-alcohol
0 ImagesCat. No.: HY-140805CAS No.: 1637297-21-2Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG20-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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t-Boc-Aminooxy-PEG4-amine
0 ImagesCat. No.: HY-143821CAS No.: 2496687-02-4
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(1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate
0 ImagesCat. No.: HY-W890392CAS No.: 2866254-09-1
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APN-NH2
0 ImagesCat. No.: HY-140348CAS No.: 1539292-61-9
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Ald-Ph-amido-PEG2-C2-acid
0 ImagesCat. No.: HY-130154CAS No.: 1807534-84-4
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Mal-PEG5-PFP ester
0 ImagesCat. No.: HY-133210CAS No.: 1807512-46-4
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Boc-aminooxy-PEG5-propargyl
0 ImagesCat. No.: HY-140053CAS No.: 2086688-98-2
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Boc-Aminooxy-PEG4-CH2-Boc
0 ImagesCat. No.: HY-140420CAS No.: 2062663-63-0
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Azidoethyl-SS-PEG2-Boc
0 ImagesCat. No.: HY-140107CAS No.: 2144777-83-1Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azidoethyl-SS-PEG2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-(m-PEG8-amido)-hexanoic acid
0 ImagesCat. No.: HY-141290CAS No.: 2353409-77-3
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1,1,1-Trifluoroethyl-PEG4-Tos
0 ImagesCat. No.: HY-140379CAS No.: 1872433-61-8
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t-Boc-Aminooxy-PEG7-methane
0 ImagesCat. No.: HY-140437CAS No.: 2055041-27-3
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N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5
0 ImagesCat. No.: HY-141053CAS No.: 2107273-54-9N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Mal-PEG3-NH2
0 ImagesCat. No.: HY-W190796CAS No.: 2170654-70-1Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a crosslinking reagent with a PEG spacer.
