PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
Tetrazine-Ph-PEG4-Ph-aldehyde
0 ImagesCat. No.: HY-133465Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
-
DBCO-PEG4-NH-Boc
0 ImagesCat. No.: HY-140291CAS No.: 2353410-17-8
-
Azido-PEG35-amine
0 ImagesCat. No.: HY-140220CAS No.: 2301851-71-6Azido-PEG35-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG35-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Methylamino-PEG2-acid
0 ImagesCat. No.: HY-140153CAS No.: 1807503-87-2
-
Hydroxy-PEG1-C2-methyl ester
0 ImagesCat. No.: HY-141239CAS No.: 93673-82-6Synonyms: Methyl 3-(2-hydroxyethoxy)propanoate
-
Tos-PEG9-Boc
0 ImagesCat. No.: HY-125534CAS No.: 1345337-28-1
-
Azido-PEG13-acid
0 ImagesCat. No.: HY-138435Azido-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG13-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Fmoc-NH-PEG3-amide-CH2OCH2COOH
0 ImagesCat. No.: HY-W096128CAS No.: 489427-26-1
-
N,N'-bis-(propargyl-PEG4)-Cy5
0 ImagesCat. No.: HY-141054CAS No.: 2107273-08-3
-
NH2-C-Ph-hexyne-C4-NH2
0 ImagesCat. No.: HY-184457CAS No.: 2441860-09-7NH2-C-Ph-hexyne-C4-NH2 is a PROTAC linker. NH2-C-Ph-hexyne-C4-NH2 can connect the BRD4 ligand JQ1 (HY-13030) with the SYVN1 ligand Clofibric acid (HY-B1415), thereby achieving the degradation of BRD4 via the PROTAC mechanism. NH2-C-Ph-hexyne-C4-NH2 can be used for the synthesis of PROTAC BRD4 Degrader-47 (HY-184455).
-
Propargyl-PEG-acid
0 ImagesCat. No.: HY-143820CAS No.: 1421676-62-1
-
Fmoc-NMe-PEG4-NHS ester
0 ImagesCat. No.: HY-141103CAS No.: 2228857-30-3
-
Benzyl-PEG7-Ots
0 ImagesCat. No.: HY-138710CAS No.: 3031623-20-5
-
MS-PEG4-THP
0 ImagesCat. No.: HY-W096074CAS No.: 145927-73-7
-
Hydroxy-PEG16-Boc
0 ImagesCat. No.: HY-130833CAS No.: 2592433-80-0
-
Bromo-PEG2-THP
0 ImagesCat. No.: HY-W096071CAS No.: 152065-54-8
