PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Propargyl-PEG7-NHS ester
0 ImagesCat. No.: HY-130381CAS No.: 2093152-77-1Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG7-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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THP-PEG10-THP
0 ImagesCat. No.: HY-134747CAS No.: 42749-29-1
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Fluorescein-PEG3-NH-Boc
0 ImagesCat. No.: HY-141081CAS No.: 1807534-77-5
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Methyl acetate-PEG1-methyl acetate
0 ImagesCat. No.: HY-134716CAS No.: 54665-51-9
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OPSS-PEG8-COOH
0 ImagesCat. No.: HY-130348CAS No.: 1334177-96-6
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Bromo-PEG1-NH2 hydrobromide
0 ImagesCat. No.: HY-134736CAS No.: 2287287-20-9
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DBCO-PEG1-NH-Boc
0 ImagesCat. No.: HY-140289CAS No.: 2364591-77-3
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Decaethylene glycol dodecyl ether
0 ImagesSynonyms: PEG10-dodecyl
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N3-PEG5000-NH2
0 ImagesCat. No.: HY-W1048572EN3-PEG5000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG5000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester.
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3,4-Dibromo-Mal-PEG4-Boc
0 ImagesCat. No.: HY-141006CAS No.: 2030168-38-6
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N-(Azido-PEG3)-N-bis(PEG4-Boc)
0 ImagesCat. No.: HY-140869CAS No.: 2353409-58-0N-(Azido-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-bis(PEG4-Boc) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Cbz-PEG5-Br
0 ImagesCat. No.: HY-143832CAS No.: 2710803-69-1
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5-(Biotinamido)pentylazide
0 ImagesCat. No.: HY-134695CAS No.: 1349190-76-65-Biotinamidopentylazide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-(Biotinamido)pentylazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Mal-amido-PEG7-acid
0 ImagesSynonyms: Mal-NH-PEG7-COOH; Maleimide-NH-PEG7-CH2CH2COOH
